Концепция эндофенотипа: новый подход к изучению патогенеза аффективных расстройств (аналитический обзор). Часть 1

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Вазагаева Т.И., Ахапкин Р.В. Концепция эндофенотипа: новый подход к изучению патогенеза аффективных расстройств (аналитический обзор). Часть 1 // Российский психиатрический журнал. 2013. №3. С. 22-31.

Аннотация

В статье описываются современные подходы к изучению этиопатогенеза аффективных расстройств, характеризующихся генетической и фенотипической неоднородностью, на основе выявления диагностических и прогностических биомаркеров и эндофенотипов. Приводятся данные зарубежной литературы о нейропсихологических и когнитивных кандидатах-эндофенотипах, выявляемых в семейных и близнецовых наблюдениях с привлечением молекулярно-генетических исследований. Анализируется обоснованность использования в качестве эндофенотипов отдельных нейрокогнитивых показателей у пациентов с аффективными расстройствами, обнаруживающихся как у больных, так и у их здоровых родственников с усилением выраженности пропорционально повышению генетического родства и тесно связанных с полиморфизмом генов.

Ключевые слова эндофенотипы; аффективные расстройства; нейрокогнитивные и нейропсихологические исследования; генетические исследования

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