Микробиом кишечника человека и психическое здоровье: состояние проблемы

Полный текст:
Читать

Рекомендуемое оформление библиографической ссылки:

Барыльник Ю.Б., Шульдяков А.А., Филиппова Н.В., Рамазанова К.Х. Микробиом кишечника человека и психическое здоровье: состояние проблемы // Российский психиатрический журнал. 2015. №3. С. 30-41.

Аннотация

Депрессивные расстройства в последние годы занимают одно из ведущих мест среди причин инвалидности во всем мире. В этой связи чрезвычайно актуальным представляется выявление новых мишеней профилактики и лечения депрессий. Современные исследования подтверждают значимую роль микробиома кишечника в регуляции психических функций, в частности настроения и поведения. Кроме того, исследования последних лет доказали, что неправильное питание в значительной степени коррелирует с депрессивными расстройствами и является одним из факторов риска развития депрессии. В данном обзоре проведен анализ исследований, свидетельствующих о том, что микрофлора кишечника является ключевым фактором, опосредующим взаимосвязь между особенностями питания и депрессивными расстройствами.

Литература

1. Власов В.В. Микробный "орган" человека // Наука из первых рук. 2014. № 1 (55). С. 32-34. 2. Гасбаррини А. Микрофлора и "болезни цивилизации" // Последипломный курс EAGEN "Микрофлора кишечника у здоровых и больных": европейские знания и опыт в Украине. 2014. [Электронный ресурс]. Режим доступа http://health-ua.com/pics/pdf/ZU_2014_GastRo_2/17.pdf. 3. Керш Г. Эволюция кишечной микрофлоры на протяжении жизни человека // Последипломный курс EAGEN "Микрофлора кишечника у здоровых и больных": европейские знания и опыт в Украине. 2014 [Электронный ресурс] Режим доступа: http://health-ua.com/pics/pdf/ZU_2014_GastRo_2/17.pdf. 4. Милославлевич Т. Микробиом кишечника человека и его физиологическая роль // Последипломный курс EAGEN "Микрофлора кишечника у здоровых и больных": европейские знания и опыт в Украине. 2014 [Электронный ресурс] Режим доступа: http://health-ua.com/pics/pdf/ZU_2014_GastRo_2/17.pdf. 5. Мошкин М.П. Невидимый кукловод // Наука из первых рук.2014. № 1(55). [Электронный ресурс]. Режим доступа:http://www.sciencefirsthand.ru/c55_01_09.shtml. 6. Харченко Н.В. Пробиотики и пребиотики // Последипломный курс EAGEN "Микрофлора кишечника у здоровых и больных": европейские знания и опыт в Украине. 2014. Электронный ресурс. Режим доступа http://health-ua.com/pics/pdf/ZU_2014_GastRo_2/17.pdf. 7. Albenberg L.G., Wu G.D. Diet and the intestinal microbiome: associations, functions, and implications for health and disease // Gastroenterology.2014. Vol. 146. P. 1564-1572. 8. Alcock J., Maley C.C., Aktipis C.A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms // BioEssays. 2014. Vol. 36. P. 940-949. 9. Bailey M.T., Lubach G.R., Coe C.L. Prenatal stress alters bacterial colonization of the gut in infant monkeys // J. Pediatr. Gastroenterol. Nutr. 2004. Vol. 38. P. 414-421. 10. Ballongue J., Schumann C., Quignon P. Effects of lactulose and lactitol on colonic microflora and enzymatic activity Scandinavian // J. Gastroenterol. 1997. Vol. 32, suppl. 22. P. 41-44. 11. Battersby A.J., Gibbons D.L. The gut mucosal immune system in the neonatal period // Pediatr. Allergy. Immunol. 2013. Vol. 24. P. 414-421. 12. Bercik P., Denou E., Collins J. et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice //Gastroenterology. 2011. Vol. 141. P. 599-609. 13. Berk M., Williams L.J., Jacka F.N. et al. So depression is an inflammatory disease, but where does the inflammation come from? // BMC Med. 2013. Vol. 11. P. 200. 14. Bested A.C., Logan A.C., Selhub E.M. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part I: autointoxication revisited // Gut Pathog. 2013. Vol. 5. P. 5. 15. Biagi Е., Nylund L., Candela M. et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians // PLoS One. 2010. Vol. 17, N 5. P. e10667. [Электронный ресурс]. Режим доступа: http://www.pubfacts.com/detail/20498852/Throughageingand-beyond:-gut-microbiota-and-inflammatory-status-inseniorsand-centenarians. 16. Bravo J.A., Forsythe P., Chew M.V. et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve // Proc. Natl Acad. Sci. USA. 2011. Vol. 108. P. 16050-16055. 17. Bruce-Keller A.J., Salbaum J.M., Luo M. et al. Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity // Biol. Psychiatry. 2014. doi: 10.1016/j.biopsych.2014.07.012. [Epub ahead of print]. 18. Cho C.E., Norman M. Cesarean section and development of the immune system in the offspring // Am. J. Obstet. Gynecol. 2013. Vol. 208. P. 249-254. 19. Claesson M.J., Jeffery I.B., Conde S. et al. Gut microbiota composition correlates with diet and health in the elderly // Nature. 2012. Vol. 488. P. 178-184. 20. Clarke G., Grenham S., Scully P. et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner // Mol. Psychiatry. 2013. Vol. 18. P. 666-673. 21. Clarke G., O’Mahony S., Dinan, T.G. et al. Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour // Acta. Paediatr. 2014. Vol. 103. P. 812-819. 22. Clarke S.F., Murphy E.F., O’Sullivan O. et al. Exercise and associated dietary extremes impact on gut microbial diversity // Gut. 2014. doi: 10.1136/gutjnl-2013-306541. [Epub ahead of print]. 23. Clarke G., Stilling R.M., Kennedy P.J. et al. Minireview: gut microbiota: the neglected endocrine organ // Mol. Endocrinol. 2014. Vol. 28. P. 1221-1238. 24. Collins S.M., Surette M., Bercik P. The interplay between the intestinal microbiota and the brain // Nat. Rev. Microbiol. 2012. Vol. 10. P. 735-742. 25. Crumeyrolle-Arias M., Jaglin M., Bruneau A. et al. Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats // Psychoneuroendocrinology. 2014. Vol. 42. P. 207-217. 26. Cryan J.F., Dinan T.G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour // Nat. Rev. Neurosci. 2012. Vol. 13. P. 701-712. 27. Davey K.J., Cotter P.D., O’Sullivan O. et al. Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat // Transl. Psychiatry. 2013. Vol. 3. P. e309. 28. David L.A., Maurice C.F., Carmody R.N. et al. Diet rapidly and reproducibly alters the human gut microbiome // Nature. 2014. Vol. 505. P. 559-563. 29. De Filippo C., Cavalieri D., Di Paola M. et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa // Proc. Natl Acad. Sci. USA. 2010. Vol. 107. P. 14691-14696. 30. Del Chierico F., Vernocchi P., Dallapiccola B. et al. Mediterranean diet and health: food effects on gut microbiota and disease control // Int. J. Mol. Sci. 2014. Vol. 15. P. 11678-11699. 31. Desbonnet L., Garrett L., Clarke G. et al. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. // Neurscience. 2010. Vol. 170. P. 1179-1188. 32. Desbonnet L., Clarke G., Shanahan F. et al. Microbiota is essential for social development in the mouse // Mol. Psychiatry. 2014. Vol. 19. P. 146-148. 33. Dethlefsen L., Huse S., Sogin M.L. et al. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing // PLoS Biol. 2008. Vol. 6. P. e280. 34. Diaz Heijtz R., Wang S., Anuar F. et al. Normal gut microbiota modulates brain development and behavior // Proc. Natl Acad. Sci. USA. 2011. Vol. 108. P. 3047-3052. 35. Dinan T.G., Cryan J.F. Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology // Psychoneuroendocrinology. 2012. Vol. 37. P. 1369-1378. 36. Dominguez-Bello M.G., Costello E.K., Contreras M. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns // Proc. Natl Acad. Sci. USA. 2010. Vol. 107. P. 11971-11975. 37. Fallani M., Young D., Scott J. et al. Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics // J. Pediatr. Gastroenterol. Nutr. 2010. Vol. 51. P. 77-84. 38. Fasano A. Leaky gut and autoimmune diseases // Clin. Rev. Allergy. Immunol. 2012. Vol. 42. P. 71-78. 39. Foster J.A., McVey Neufeld K.A. Gut-brain axis: how the microbiome influences anxiety and depression // Trends Neurosci. 2013. Vol. 36. P. 305-312. 40. Fraher M.H., O’Toole P.W., Quigley E.M. Techniques used to characterize the gut microbiota: a guide for the clinician // Nat. Rev. Gastroenterol. Hepatol. 2012. Vol. 9. P. 312-322. 41. Gareau M.G., Wine E., Rodrigues D.M. et al. Bacterial infection causes stress-induced memory dysfunction in mice // Gut. 2011. Vol. 60. P. 307-317. 42. Grenham S., Clarke G., Cryan J.F. et al. Brain-gut-microbe communication in health and disease // Front Physiol. 2011. Vol. 2. P. 94. 43. Guinane C.M., Cotter P.D. Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ // Ther. Adv. Gastroenterol. 2013. Vol. 6. P. 295-308. 44. Hamaker B.R., Tuncil Y.E. A perspective on the complexity of dietary fiber structures and their potential effect on the gut microbiota // J. Mol. Biol. 2014. doi: 10.1016/j.jmb.2014.07.028. [Epub ahead of print]. 45. Hollander D. Intestinal permeability, leaky gut, and intestinal disorders // Curr. Gastroenterol. Rep. 1999. Vol. 1. P. 410-416. 46. Hooper L.V., Littman D.R., Macpherson A.J. Interactions between the microbiota and the immune system // Science. 2012. Vol. 336. P. 1268-1273. 47. Jacka F.N., Kremer P.J., Leslie E.R. et al. Associations between diet quality and depressed mood in adolescents: results from the Australian Healthy Neighbourhoods Study // Aust. N.Z. J. Psychiatry. 2010. Vol. 44. P. 435-442. 48. Jacka F.N., Mykletun A., Berk M. Moving towards a population health approach to the primary prevention of common mental disorders // BMC Med. 2012. Vol. 10. P. 149. 49. Jacka F.N., Ystrom E., Brantsaeter A.L. et al. Maternal and early postnatal nutrition and mental health of offspring by age 5 years: a prospective cohort study // J. Am. Acad. Child. Adolesc. Psychiatry. 2013. Vol. 52. P. 1038-1047. 50. Jacka F.N., Sacks G., Berk M. et al. Food policies for mental and physical health // BMC Psychiatry. 2014. Vol. 14. P. 132. 51. Kaczmarkczyk M.M., Miller M.J., Freund G.G. The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer // Metabolism. 2012. Vol. 61. P. 1058-1066. 52. Kim K.A., Gu W., Lee I.A. et al. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway // PLoS One. 2012. Vol. 7. P. e47713. 53. Knowles S.R., Nelson E.A., Palombo E.A. Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness // Biol. Psychol. 2008. Vol. 77. P. 132-137. 54. Kubera M., Curzytek K., Duda W. et al. A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months // Brain Behav. Immun. 2013. Vol. 31. P. 96-104. 55. Lai J.S., Hiles S., Bisquera A. et al. A systematic review and metaanalysis of dietary patterns and depression in community-dwelling adults // Am. J. Clin. Nutr. 2014. Vol. 99. P. 181-197. 56. Lepage P., Leclerc M.C., Joossens M. et al. A metagenomic insight into our gut’s microbiome // Gut. 2013. Vol. 62. P. 146-158. 57. Lewis A.J., Galbally M., Gannon T. et al. Early life programming as a target for prevention of child and adolescent mental disorders // BMC Med. 2014. Vol. 12. P. 33. 58. Li W., Dowd S.E., Scurlock B. et al. Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria // Physiol. Behav. 2009. Vol. 96. P. 557-567. 59. Maes M. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression // Neuroendocrinol. Lett. 2008. Vol. 29. P. 287-291. 60. Maes M., Kubera M., Leunis J.C. et al. Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut // J. Affect. Disord. 2012. Vol. 141. P. 55-62. 61. Maes M., Ringel K., Kubera M. et al. In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation // J. Affect. Disord. 2013. Vol. 150. P. 223-230. 62. Maslowski K.M., Mackay C.R. Diet, gut microbiota and immune responses // Nat. Immunol. 2011. Vol. 12. P. 5-9. 63. Mayer E.A., Naliboff B., Munakata J. The evolving neurobiology of gut feelings // Prog. Brain. Res. 2000. Vol. 122. P. 195-206. 64. Mayer E.A. Gut feelings: the emerging biology of gut-brain communication // Nat. Rev. Neurosci. 2011. Vol. 12. P. 453-466. 65. Mayer E.A., Savidge T., Shulman R.J. Brain-gut microbiome interactions and functional bowel disorders // Gastroenterology. 2014. Vol. 146. P. 1500-1512. 66. Mello B.S., Monte A.S., McIntyre R.S. et al. Effects of doxycycline on depressivelike behavior in mice after lipopolysaccharide (LPS) administration // J. Psychiatr. Res. 2013. Vol. 47. P. 1521-1529. 67. Messaoudi M., Violle N., Bisson J.F. et al. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers // Gut Microbes. 2011. Vol. 2. P. 256-261. 68. Molina-Hernandez M., Tellez-Alcantara N.P., Perez-Garcia J. et al. Antidepressant-like actions of minocycline combined with several glutamate antagonists // Prog. Neuropsychopharmacol. Biol. Psychiatry. 2008. Vol. 32. P. 380-386. 69. Moloney R.D., Desbonnet L., Clarke G. et al. The microbiome: stress, health and disease // Mamm. Genome. 2014. Vol. 25. P. 49-74. 70. Naseribafrouei A., Hestad K., Avershina E. et al. Correlation between the human fecal microbiota and depression // Neurogastroenterol. Motil. 2014. Vol. 26. P. 1155-1162. 71. Neufeld K.M., Kang N., Bienenstock J. et al. Reduced anxiety-like behavior and central neurochemical change in germ-free mice // Neurogastroenterol. Motil. 2011. Vol. 23. P. 255-264. 72. Nieuwdorp M., Gilijamse P.W., Pai N. et al. Role of the microbiome in energy regulation and metabolism // Gastroenterology. 2014. Vol. 146. P. 1525-1533. 73. Odenwald M.A., Turner J.R. Intestinal permeability defects: is it time to treat? // Clin. Gastroenterol. Hepatol. 2013. Vol. 11. P. 1075-1083. 74. O’Hara A.M., Shanahan F. The gut flora as a forgotten organ // EMBO Rep. 2006. Vol. 7. P. 688-693. 75. Ohland C.L., Kish L., Bell H. et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome // Psychoneuroendocrinology. 2013. Vol. 38. P. 1738-1747. 76. O’Mahony S.M., Marchesi J.R., Scully P. et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses // Biol. Psychiatry. 2009. Vol. 65. P. 263-267. 77. O’Mahony S.M., Clarke G., Borre Y.E. et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis // Behav. Brain. Res. 2014. doi: 10.1016/j.bbr.2014.07.027. [Epub ahead of print]. 78. O’Neil A., Berk M., Itsiopoulos C. et al. A randomised, controlled trial of a dietary intervention for adults with major depression (the ‘SMILES’ trial): study protocol // BMC Psychiatry. 2013. Vol. 13. P. 114. 79. O’Neil A., Quirk S.E., Housden S.L. et al. The relationship between diet and mental health in children and adolescents: a systematic review // Am. J. Public Health. 2014. Vol. 104. P. e31-e42. 80. Park A.J., Collins J., Blennerhassett P.A. et al. Altered colonic function and microbiota profile in a mouse model of chronic depression // Neurogastroenterol. Motil. 2013. Vol. 25. P.е733-e575. 81. Power S.E., O’Toole P.W., Stanton C., et al. Intestinal microbiota, diet and health // Br. J. Nutr. 2014. Vol. 111. P. 387-402. 82. Psaltopoulou T., Sergentanis T.N., Panagiotakos D.B. et al. Mediterranean diet, stroke, cognitive impairment, and depression: a metaanalysis // Ann. Neurol. 2013. Vol. 74. P. 580-591. 83. Qin L., Wu. X., Block M.L. et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration // Glia. 2007. Vol. 55. P. 453-462. 84. Relman D.A. The human microbiome: ecosystem resilience and health // Nutr. Rev. 2012. Vol. 70, suppl. 1. P. S2-S9. 85. Ritchie M.L., Romanuk T.N. A meta-analysis of probiotic efficacy for gastrointestinal diseases // PLoS One. 2012. Vol. 7. P. e34938. 86. Rhee S.H., Pothoulakis C., Mayer E.A. Principles and clinical implications of the brain-gut-enteric microbiota axis // Nat. Rev. Gastroenterol. Hepatol. 2009. Vol. 6. P. 306-314. 87. Sanchez-Villegas A., Martinez-Gonzalez M.A. Diet, a new target to prevent depression? // BMC Med. 2013. Vol. 11. P. 3. 88. Sanchez-Villegas A., Martinez-Gonzalez M.A., Estruch R. et al. Mediterranean dietary pattern and depression: the PREDIMED randomized trial // BMC Med. 2013. Vol. 11. P. 208. 89. Scheppach W, Luehrs H., Menzel T. Beneficial health effects of lowdigestible carbohydrate consumption // Br. J. Nutr. 2001. Vol. 85, suppl. 1. P. S23-S30. 90. Selhub E.M., Logan A.C., Bested A.C. Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry // J. Physiol. Anthropol. 2014. Vol. 33. P. 2. 91. Sommer M.O., Dantas G. Antibiotics and the resistant microbiome // Curr. Opin. Microbiol. 2011. Vol. 14. P. 556-563. 92. Sommer F., Backhed F. The gut microbiota - masters of host development and physiology // Nat. Rev. Microbiol. 2013. Vol. 11. P. 227-238. 93. Stahl S.T., Albert S.M., Dew M.A. et al. Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention // Am. J. Psychiatry. 2014. Vol. 171. P. 499-505. 94. Steenweg-de Graaff J., Tiemeier H., Steegers-Theunissen R.P. et al. Maternal dietary patterns during pregnancy and child internalising and externalizing problems. The Generation R. Study // Clin. Nutr. 2014. Vol. 33. P. 115-121. 95. Sudo N., Chida Y., Aiba Y. et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice // J. Physiol. 2004. Vol. 558, pt 1. P. 263-275. 96. Tillisch K., Labus J., Kilpatrick L. et al. Consumption of fermented milk product with probiotic modulates brain activity // Gastroenterology. 2013. Vol. 144. P. 1394-1401. 97. Whitaker K.M., Sharpe P.A., Wilcox S. et al. Depressive symptoms are associated with dietary intake but not physical activity among overweight and obese women from disadvantaged neighborhoods // Nutr. Res. 2014. Vol. 34. P. 294-301. 98. Whiteford H.A., Degenhardt L., Rehm J. et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010 // Lancet. 2013. Vol. 382. P. 1575-1586. 99. Wu G.D., Chen J., Hoffmann C. et al. Linking long-term dietary patterns with gut microbial enterotypes // Science. 2011. Vol. 334. P. 105-108. 100. Yatsunenko T., Rey F.E., Manary M.J. et al. Human gut microbiome viewed across age and geography // Nature. 2012. Vol. 486. P. 222- 227. 101. Zareie M., Johnson-Henry K., Jury J. et al. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress // Gut. 2006. Vol. 55. P. 1553-1560. 102. Zhu B., Wang X., Li L. Human gut microbiome: the second genome of human body // Protein Cell. 2010. Vol. 1. P. 718-725.

Метрики статей

Загрузка метрик ...

Metrics powered by PLOS ALM