Концепция эндофенотипа: новый подход к изучению патогенеза аффективных расстройств (аналитический обзор). Часть 2

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Вазагаева Т.И., Ахапкин Р.В. Концепция эндофенотипа: новый подход к изучению патогенеза аффективных расстройств (аналитический обзор). Часть 2 // Российский психиатрический журнал. 2013. №4. С. 37-48.

Аннотация

В статье проводится систематический анализ результатов нейробиологических исследований, направленных на поиск кандидатов-эндофенотипов при аффективных расстройствах, занимающих промежуточное положение между генетическими факторами и клиническими проявлениями заболевания. Описываются нейровизуализационные (структурные и функциональные) и нейрохимические нарушения, выявляемые при аффективной патологии, такие как гиперинтенсивность белого вещества мозга, повышенная активация миндалины и орбитофронтальной коры, патологические изменения нейротрофических факторов и концентраций различных нейрохимических субстратов и нейротрансмиттеров в определенных областях мозга и др., наиболее специфично и доказательно отражающие этиопатогенетические механизмы развития болезненного процесса.

Ключевые слова эндофенотипы; аффективные расстройства; нейровизуализационные; нейрохимические и генетические исследования

Литература

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