Изменения Р100 и N170 при восприятии лицевой экспрессии у пациентов с шизофренией и шизоаффективным расстройством

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Спектор В.А., Мнацаканян Е.В., Шмуклер А.Б. Изменения Р100 и N170 при восприятии лицевой экспрессии у пациентов с шизофренией и шизоаффективным расстройством // Российский психиатрический журнал. 2020. №6. С. 82-92.

Аннотация

В пилотном исследовании с целью изучения вызванных потенциалов были обследованы 10 пациентов с шизофренией, 8 пациентов с шизоаффективным расстройством и 16 здоровых лиц. У больных шизофренией отмечалось увеличение латентностей Р100 и N170 в ответ на изображения любого эмоционального содержания (страх, нейтральное выражение, счастье). Пациенты с шизоаффективным расстройством в этих случаях продемонстрировали минимальные латентности обоих пиков. А показатели группы сравнения оказались между показателями групп пациентов с шизофренией и шизоаффективным расстройством. Также в группе пациентов с шизоаффективным расстройством наблюдалась положительная корреляция позитивной симптоматики PANSS с латентностями пиков P100 и N170. Предполагается, если при увеличении выборки различия между группами пациентов будут сохраняться, вероятно, их можно будет использовать как дифференциально-диагностический биомаркер.

Ключевые слова шизофрения; шизоаффективное расстройство; восприятие лицевой экспрессии; вызванные потенциалы; P100; N170

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DOI: http://dx.doi.org/10.24411/1560-957Х-2020-10610

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