Молекулярные маркеры предрасположенности человека к совершению действий суицидального характера
Рекомендуемое оформление библиографической ссылки:
Печенкина А.А., Тюнева А.И., Цыганков Б.Д. Молекулярные маркеры предрасположенности человека к совершению действий суицидального характера // Российский психиатрический журнал. 2021. №4. С. 68-79.
В научном обзоре с целью структурирования достижений молекулярной медицины в области суицидологии и определения конкретных, прогностически наиболее ценных молекулярных маркеров (генетических, эпигенетических и биохимических детерминант) предрасположенности человека к совершению действий суицидального характера был проведён анализ литературных данных. В результате было определено, что в настоящее время по изучаемой теме существует 4 основных научных направления: серотонинергическая модель, модель эпигенетических изменений, модель липидного обмена и прочие модели; в данной работе собраны воедино достижения молекулярной суицидологии. Отдельно вынесена на обсуждение тема так называемой молекулярной коморбидности суицида и других патологий, имеющих с ним глубинные пересечения на уровне биохимии и эпигенетики, что следует учитывать при составлении программы терапии и консультации пациентов.
Ключевые слова суицидальные намерения; суицидальное поведение; молекулярная суицидология; серотонинергическая система; метилирование ДНК
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DOI: http://dx.doi.org/10.47877/1560-957Х-2021-10408
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