Сравнение результатов теста AUDIT и лабораторного контроля фосфатидилэтанола в крови с целью определения характера потребления алкоголя у пациентов с циррозом печени алкогольной этиологии
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Иконникова К.А., Ерощенко Н.Н., Клименко Т.В., Дроздов В.Н., Ших Е.В. Сравнение результатов теста AUDIT и лабораторного контроля фосфатидилэтанола в крови с целью определения характера потребления алкоголя у пациентов с циррозом печени алкогольной этиологии // Российский психиатрический журнал. 2022. №1. С. 73-80.
Проведено когортное обсервационное исследование с целью сопоставления характера употребления алкоголя по результатам AUDIT (Alcohol Use Disorders Inventory Test) с содержанием в крови биомаркера алкоголя фосфатидилэтанола (ФЭ) у мужчин старше 18 лет (n=112) с алкогольным поражением печени в анамнезе. Расстройство употребления алкоголя по результатам AUDIT (≥8 баллов) обнаружено у 52 (46,4%) пациентов, при этом ФЭ в крови выявлен у 74 человек (66%). В группе с 0–7 баллов по AUDIT ФЭ обнаружен в 36,6% случаев, в группе с 16–19 баллами – в 100%. В группе с ≥20 баллов по AUDIT маркер обнаружен у 5 из 8 пациентов (62,5%) в диапазоне концентраций 61,2–251,1 нг/мл, следовательно, в этой группе оказались пациенты с разным характером потребления, что характерно и для других групп. Не отмечено взаимосвязи между уровнем ФЭ и результатами AUDIT. Пациенты испытывали трудность с заполнением вопросника, поэтому целесообразно включать лабораторную диагностику ФЭ в обследование пациентов с подозрением на чрезмерное потребление алкоголя.
Ключевые слова Alcohol Use Disorders Inventory Test (AUDIT); фосфатидилэтанол; биомаркеры употребления алкоголя
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DOI: http://dx.doi.org/10.47877/1560-957Х-2022-10109
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