Краткая история формирования концепции резистентной депрессии и детальная история применения при этом состоянии необратимых неселективных ИМАО (к 70-летию этой группы антидепрессантов)

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Данилов Д.С. Краткая история формирования концепции резистентной депрессии и детальная история применения при этом состоянии необратимых неселективных ИМАО (к 70-летию этой группы антидепрессантов) // Российский психиатрический журнал. 2022. №4. С. 83-94.

Аннотация

В научном историческом обзоре, приуроченном к 70-летию начала использования необратимых неселективных ингибиторов моноаминоксидазы у больных депрессией, кратко систематизирована история формирования концепции резистентной депрессии; проанализированы разногласия в отношении критериев этого понятия; детально систематизированы истории изучения эффективности и применения при резистентной депрессии ингибиторов моноаминоксидазы и их комбинации с трициклическими антидепрессантами; проанализированы разные точки зрения в отношении вопроса рациональности такой терапии. Описание исторических событий охватывает почти 60-летний период – от момента появления первых сообщений в середине 60-х годов XX века до конца второго десятилетия XXI века.

Ключевые слова необратимые неселективные ингибиторы моноаминоксидазы; ИМАО; комбинация ИМАО и ТЦА; антидепрессанты; резистентная депрессия; история оценки эффективности; история применения

Литература

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DOI: http://dx.doi.org/10.47877/1560-957Х-2022-10410

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