Нейрокогнитивные корреляты биполярного аффективного расстройства

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Шипкова К.М., Довженко Т.В. Нейрокогнитивные корреляты биполярного аффективного расстройства // Российский психиатрический журнал. 2022. №5. С. 30-38.

Аннотация

В научном обзоре с целью анализа рассмотрены публикации, предметом которых были нейрокогнитивные корреляты биполярного аффективного расстройства, специфика нейрокогнитивного профиля и прогностические критерии оценки его реабилитационного потенциала. Показано, что при биполярном аффективном расстройстве нарушаются базовые компоненты регуляции поведения и их производные: построение умозаключений, планирование деятельности, решение сложных поведенческих и мыслительных задач. Биполярное аффективное расстройство влияет на продуктивность процессов «холодного» и «горячего» познания, тормозных процессов, рабочей памяти, внимания, формирует когнитивную ригидность. Нейрокогнитивный дефицит носит стойкий характер и не регрессирует в эутимном периоде. При биполярном аффективном расстройстве формируются морфологические изменения в дорсолатеральной, орбитофронтальной, вентромедиальной префронтальной коре, передней поясной извилине, амигдале; отмечается уменьшение толщины серого вещества.

Ключевые слова биполярное аффективное расстройство; нейрокогнитивные корреляты; нейропсихологическая диагностика; нейрокогнитивный дефицит; эндофенотип

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DOI: http://dx.doi.org/10.47877/1560-957Х-2022-10503

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