Основные сигнальные пути, вовлеченные в патогенез онкологических заболеваний и психических нарушений

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Кит О.И., Владимирова Л.Ю., Шпорт С.В., Льянова А.А., Бобров А.Е., Геворкян Э.Ю., Зайцева А.Д. Основные сигнальные пути, вовлеченные в патогенез онкологических заболеваний и психических нарушений // Российский психиатрический журнал. 2023. №5. С. 66-80.

Аннотация

В научном обзоре с целью освещения смежных проблем в онкологии и психиатрии с позиции особенностей генетических, молекулярных и клеточных факторов, связанных с психическими заболеваниями и раком, а также изучения возможностей использования в психиатрии достижений в персонализированной онкологии, рассмотрены различные молекулярные мишени с доказанным участием в возникновении онкологических заболеваний в плане их потенциального значения при развитии психических расстройств и клинической значимости прецизионного генетического тестирования в психиатрии. Представлены сигнальные пути МАРК, PI3K/AKT/mTOR, VEGF, МЕТ, NOTCH, а также герминальные мутации семейства BRCA. Наряду с этим обсуждается ряд проблем, которые необходимо преодолеть в будущем в прецизионной психиатрии при применении геномного тестирования, такие как обширная полигенность и плейотропия. Одним из шагов на этом пути может быть использование подходов и полученных знаний в молекулярной онкологии.

Ключевые слова онкология; психиатрия; онкопсихиатрия; NGS; сигнальные пути; МАРК; PI3K/AKT/mTOR; VEGF; BRCA; NOTCH; MET; депрессия; биполярное аффективное расстройство; расстройство аутистического спектра; полигенность; плейотропия; прецизионная психиатрия

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DOI: http://dx.doi.org/10.34757/1560-957X.2023.27.5.008

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