Нейрокогнитивные нарушения у больных шизофренией с синдромом зависимости от алкоголя
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Галкин С.А., Корнетова Е.Г., Корнетов А.Н., Сорокина В.А., Бохан Н.А. Нейрокогнитивные нарушения у больных шизофренией с синдромом зависимости от алкоголя // Российский психиатрический журнал. 2025. №2. С. 48-54.
В эмпирическом исследовании с целью изучения показателей когнитивного функционирования у больных шизофренией с синдромом зависимости от алкоголя и без коморбидной алкогольной патологии было обследовано 274 пациента. Для выявления нейрокогнитивного дефицита использована Шкала краткой оценки когнитивных функций у пациентов с шизофренией (BACS). Примерно четверть (25,2%) случаев были представлены больными шизофренией с клинической картиной сформированной алкогольной зависимости. Пациенты с коморбидной патологией значительно хуже справлялись с такими заданиями, как «Последовательность чисел», «Речевая беглость», «Шифровка» и «Башня Лондона» (р<0,05). Также анализ с применением критерия χ2 показал статистически значимые различия по частоте встречаемости степени выраженности нейрокогнитивного дефицита между группами больных шизофренией с коморбидной патологией и без (p=0,016).
Ключевые слова шизофрения; коморбидность; алкогольная зависимость; нейрокогнитивный дефицит; рабочая память; семантическая беглость; внимание; исполнительные функции
1. Bosia M, Buonocore M, Bechi M, et al. Improving Cognition to Increase Treatment Efficacy in Schizophrenia: Effects of Metabolic Syndrome on Cognitive Remediation's Outcome. Front Psychiatry. 2018;9:647. DOI: 10.3389/fpsyt.2018.00647 2. Karyakina MV. [Cognitive impairment in schizophrenia: the opinion of a group of experts on the current state of the problem]. Social'naya i klinicheskaya psihiatriya [Social and Clinical Psychiatry]. 2022;32(3):83–90. (In Russ.) 3. Kornetova EG, Goncharova AA, Dmitrieva EG, et al. [The influence of clinical and therapeutic parameters on the severity of neurocognitive deficiency in patients with schizophrenia]. Byulleten' sibirskoj mediciny [Bulletin of Siberian Medicine]. 2020;19(3):36–43. (In Russ.) DOI: 10.20538/1682-0363-2020-3-36-43 4. McCutcheon RA, Keefe RSE, McGuire PK. Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment. Mol Psychiatry. 2023;28(5):1902–18. DOI: 10.1038/s41380-023-01949-9 5. Kornetova EG, Galkin SA, Mednova IA, et al. [Connections between components of metabolic syndrome and cognitive impairment in patients with schizophrenia]. Zh Nevrol Psikhiatr Im SS Korsakova. 2024;124(3):82–7. (In Russ.) DOI: 10.17116/jnevro202412403182 6. Goughari AS, Mazhari S, Pourrahimi AM, et al. Associations between components of metabolic syndrome and cognition in patients with schizophrenia. J Psychiatr Pract. 2015;21(3):190–7. DOI: 10.1097/PRA.0000000000000065 7. Kornetova EG, Galkin SA, Kornetov AN, et al. [The influence of constitutional and morphological features of patients with schizophrenia on the severity of neurocognitive deficit]. Social'naya i klinicheskaya psihiatriya [Social and Clinical Psychiatry]. 2024;34(1):26–34. (In Russ.) 8. Saglam Y, Ermis C, Tanyolac D, et al. The association between plasma thyroxine levels and neurocognitive impairment in early-onset schizophrenia and other psychosis spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2024;131:110940. DOI: 10.1016/j.pnpbp.2024.110940 9. Barbero JD, Gutiérrez-Zotes A, Montalvo I, et al. Free thyroxine levels are associated with cognitive abilities in subjects with early psychosis. Schizophr Res. 2015;166(1–3):37–42. DOI: 10.1016/j.schres.2015.04.030 10. Galkin SA, Kornetova EG, Tiguntsev VV, et al. [Spectral parameters of the electroencephalogram in patients with paranoid schizophrenia with varying degrees of neurocognitive deficiency]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2023;(4):31–8. (In Russ.) DOI: 10.34757/1560-957X.2023.27.4.003 11. Bochkarev VK, Solntseva SV, Kirenskaya AV, Tkachenko AA. [Comparative study of the characteristics of the P300 wave and induced theta rhythm in schizophrenia and personality disorders]. Zh Nevrol Psikhiatr Im SS Korsakova. 2020;120(3):41–7. (In Russ.) DOI: 10.17116/jnevro202012003141 12. Buleyko AA, Ruban DA, Nikonova NV, et al. [Schizophrenia and alcohol dependence: the problem of mutual influence]. Narkologiya. 2019;18(2):75–86. (In Russ.) DOI: 10.25557/1682-8313.2019.02.75-86 13. Archibald L, Brunette MF, Wallin DJ, Green AI. Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder. Alcohol Res. 2019;40(1):arcr.v40.1.06. DOI: 10.35946/arcr.v40.1.06 14. Leposavić L, Dimitrijević D, Đorđević S, et al. Comorbidity of harmful use of alcohol in population of schizophrenic patients. Psychiatr Danub. 2015;27(1):84–9. PMID: 25751441 15. Hunt GE, Large MM, Cleary M, et al. Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990–2017: Systematic review and meta-analysis. Drug Alcohol Depend. 2018;191:234–58. DOI: 10.1016/j.drugalcdep.2018.07.011 16. Tolmacheva VA, Kiseleva MG, Chernov NV, Kostyuk GP. [Features of cognitive impairment in persons with paranoid schizophrenia in combination with alcohol dependence syndrome]. Zh Nevrol Psikhiatr Im SS Korsakova. 2021;121(11):73–6. (In Russ.) DOI: 10.17116/jnevro202112111173 17. Litvintsev SV, Kolchev SA, Ershov BB. [Neurocognitive disorders in patients with schizophrenia in combination with alcohol dependence syndrome]. Social'naya i klinicheskaya psihiatriya [Social and Clinical Psychiatry]. 2012;22(1):28–32. (In Russ.) 18. Angerville B, Vaucher N, Gierski F, et al. Alcohol related cognitive impairments in schizophrenia patients: A case-control study. Eur Psychiatry. 2023;66:335. DOI: 10.1192/j.eurpsy.2023.734 19. Potvin S, Stavro K, Pelletier J. Paradoxical Cognitive Capacities in Dual Diagnosis Schizophrenia: The Quest for Explanatory Factors. J Dual Diagn. 2012;8:35–47. DOI: 10.1080/15504263.2012.648549 20. Thoma P, Daum I. Comorbid substance use disorder in schizophrenia: A selective overview of neurobiological and cognitive underpinnings. Psychiatry Clin Neurosci. 2013;67(6):367–83. DOI: 10.1111/pcn.12072 21. Buleyko AA, Soldatkin VA, Murina IV, et al. [Does alcoholism affect the cognitive functions of patients with schizophrenia?]. Zh Nevrol Psikhiatr Im SS Korsakova. 2019;119(7):14–9. (In Russ.) DOI: 10.17116/jnevro201911907114 22. Mazumder AH, Barnett J, Lindberg N, et al. Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder. Brain Sci. 2021;11(6):688. DOI: 10.3390/brainsci11060688 23. Mosolov SN. Scales of psychometric assessment of schizophrenia symptoms and the concept of positive and negative disorders. Moscow; 2001. 238 p. (In Russ.) 24. Kornetov AN, Yazykov KG, Kornetova EG, et al. [Normative assessment of cognitive functions on the scale “Brief assessment of cognitive functions in patients with schizophrenia” (BACS) in Tomsk population: constitutional factors of variability]. Sibirskij psihologicheskij zhurnal [Siberian Psychological Journal]. 2021;(82):137–52. (In Russ.) DOI: 10.17223/17267080/82/8 25. Sarkisyan GR, Gurovich IYa, Kif RS. [Normative data for the Russian population and standardization of the scale “Brief assessment of cognitive functions in patients with schizophrenia” (BACS)]. Social'naya i klinicheskaya psihiatriya [Social and Clinical Psychiatry]. 2010;20(3):13–9. (In Russ.) 26. Tumova MA, Shoshina II, Stanovaya VV, et al. [Indicators of cognitive functioning and characteristics of the visual system in schizophrenia: a cross-sectional study]. Psihiatriya [Psychiatry (Moscow)]. 2023;21(3):36–44. (In Russ.) DOI: 10.30629/2618-6667-2023-21-3-36-44 27. Friedman NP, Robbins TW. The role of prefrontal cortex in cognitive control and executive function. Neuropsychopharmacology. 2022;47(1):72–89. DOI: 10.1038/s41386-021-01132-0
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