Гендерные различия в ассоциированности гематологических коэффициентов воспаления с метаболическими нарушениями у пациентов с биполярным аффективным расстройством

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Попов М.Ю., Пинахина Д.В., Прусова Т.И., Лепик О.В., Бурдейная А.С., Макаревич О.В., Янушко М.Г., Мазо Г.Э. Гендерные различия в ассоциированности гематологических коэффициентов воспаления с метаболическими нарушениями у пациентов с биполярным аффективным расстройством // Российский психиатрический журнал. 2025. №4. С. 24-34.

Аннотация

В кросс-секционное ретроспективное исследование с целью оценки связи между гематологическими коэффициентами воспаления (ГКВ) и компонентами метаболического синдрома (МС) и анализа этой связи в зависимости от пола было включено 102 пациента с биполярным аффективным расстройством(БАР): 41 мужчина и 61 женщина. У пациентов с наличием и отсутствием метаболических нарушений сравнивали гематологические параметры, включая следующие ГКВ: NLR–нейтрофильно-лимфоцитарное отношение, PLR –тромбоцитарно-лимфоцитарное отношение, MLR–моноцитарно-лимфоцитарное отношение, SII–индекс системного иммунного воспаления, NHR–отношение нейтрофилов к липопротеину высокой плотности (ЛПВП), PHR–отношение тромбоцитов к ЛПВП, LHR – отношение лимфоцитов к ЛПВП. Сравнения проводили отдельно для мужчин и женщин. Выявлено, что у мужчин, в отличие от женщин, гипергликемия ассоциирована с повышением NLR и абсолютного числа нейтрофилов, а гипертриглицеридемия – с повышением общего числа лейкоцитов и абсолютного числа лимфоцитов. У женщин обнаружена связь гипертриглицеридемии с повышением индексов NHR и LHR, а также сниженного уровня ЛПВП – с повышением NHR и PHR.Полученные результаты указывают на гендерные различия в ассоциированности периферических маркеров воспаления с компонентами МС у пациентов с БАР. Воспроизводимостьвыявленных гендер-специфичных различий в «воспалительном профиле» метаболических нарушений требует подтверждения в будущих исследованиях на более крупных выборках.

Ключевые слова биполярное аффективное расстройство; риски метаболических нарушений; системное воспаление; гематологические коэффициенты воспаления

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