Prognostic role of neuromarkers in the first episode of paranoid schizophrenia before therapy
Suggested citation:
Sakharov AV, Mynduskin IV, Golygina SE. [Prognostic role of neuromarkers in the first episode of paranoid schizophrenia before therapy]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2023;(2):38-45. Russian
In a cross-sectional prospective study 40 patients diagnosed with paranoid schizophrenia, follow-up period less than a year (F20.09) were examined before therapy. Control group – 20 healthy volunteers. VILIP-1, CCL2 (MCP-1), sTREM-1, sTREM-2, BDNF, TGF-β1, VEGF, β-NGF, sRAGE, IL-6, IL-18, TNF-α, CX3CL1 in the blood serum by flow fluorimetry were determined. The sTREM-1 value exceeded the control values by 2.2 times, IL-6 and sRAGE – 1,8 times, VILIP-1 and CCL2 – 1.6 times. BDNF was reduced by 1.25 times. The results confirm the role of neuroimmune mechanisms in the development of schizophrenia. The neural network analysis established the predictive value of VILIP-1, CCL2, and sRAGE for determining the risk of developing psychosis in patients with schizophrenia.
Keywords schizophrenia; first episode; neuromarkers; cytokines; chemokines; neuroinflammation; neural network; predictive model
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