Application of the transcranial magnetic stimulation method for the treatment of cognitive dysfunction in bipolar depression
Suggested citation:
Strel'nik AI, Strel'nik SN, Markina EA, et al. [Application of the transcranial magnetic stimulation method for the treatment of cognitive dysfunction in bipolar depression]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2023;(1):91-101. Russian
In this scientific review we have carried out the analysis of the literature data in order to study changes in cognitive functions in patients with a depressive episode within the framework of bipolar affective disorder (the so-called bipolar depression) in response to the use of the transcranial magnetic stimulation method and to assess its therapeutic potential. A systematic search for articles was conducted in the Scopus and PubMed databases for the period up to March 30th, 2022. The PRISMA method was used to identify all scientific publications describing the use of transcranial magnetic stimulation in the treatment of bipolar depression and the effect of the method on the cognitive functions of patients. The works studied by us have demonstrated ambiguous results. Some data indicate the positive effect of transcranial magnetic stimulation on cognitive functions in bipolar depression. Insignificant sample size, heterogeneity of research design, absence of control groups in a number of studies, variations in stimulation parameters and outcome evaluation represent significant limitations for comparison and analysis of the results obtained. At the same time, the available data allow us to draw conclusions concerning the fundamental safety and potential effectiveness of this method.
Keywords bipolar depression; bipolar affective disorder; deep transcranial magnetic stimulation; depressive episode; cognitive functions; cognitive endophenotype; transcranial magnetic stimulation; TMS; rTMS
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