Brain-derived neurotrophic factor as a potential diagnostic biomarker of mental disorders

Full Text:   Subscribers Only

Suggested citation:

Pavlova OV, Gurina OI, Shport SV, et al. [Brain-derived neurotrophic factor as a potential diagnostic biomarker of mental disorders]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2023;(2):76-85. Russian

Abstract

In this scientific review, in order to investigate the possibility of using the levels of brain-derived neurotrophic factor in peripheral blood as a diagnostic biomarker of mental diseases, including depressive disorders, an analysis of Russian and foreign publications related to this topic was carried out. Attention is paid to the synthesis of brain-derived neurotrophic factor and its regulation in the central nervous system, the functional significance of this protein, its sources in peripheral blood are determined, and correlations of the content of this protein in the central nervous system and on the periphery are revealed.

Keywords mental disorders; biomarker; the brain-derived neurotrophic factor; BDNF; correlation of central and peripheral BDNF levels

References

1. Malhi GS, Mann JJ. Depression. Lancet. 2018;392(10161):2299–312. DOI: https://doi.org/10.1016/S0140-6736(18)31948-2 2. Bazzari AH, Bazzari FH. BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders. Int J Mol Sci. 2022;23(15):8417. DOI: https://doi.org/10.3390/ijms23158417 3. Peng S, Li W, Lv L, et al. BDNF as a biomarker in diagnosis and evaluation of treatment for schizophrenia and depression. Discov Med. 2018;26(143):127–36. PMID: 30586536 4. Hernández-Vara J, Sáez-Francàs N, Lorenzo-Bosquet C, et al. BDNF levels and nigrostriatal degeneration in “drug naïve” Parkinson’s disease patients. An “in vivo” study using I-123-FP-CIT SPECT. Parkinsonism Relat Disord. 2020;78:31–5. DOI: https://doi.org/10.1016/j.parkreldis.2020.06.037 5. Phillips C. Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection. Neural Plast. 2017;2017:7260130. DOI: https://doi.org/10.1155/2017/7260130 6. Brigadski T, Leßmann V. The physiology of regulated BDNF release. Cell Tissue Res. 2020;382(1):15–45. DOI: https://doi.org/10.1007/s00441-020-03253-2 7. Pöyhönen S, Er S, Domanskyi A, Airavaara M. Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury. N Front Physiol. 2019;10:486. DOI: https://doi.org/10.3389/fphys.2019.00486 8. Kowianski P, Lietzau G, Czuba E, et al. BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity. Cell Mol Neurobiol. 2018;38(3):579–93. DOI: https://doi.org/10.1007/s10571-017-0510-4 9. Zagrebelsky M, Tacke C. Korte M. BDNF signaling during the lifetime of dendritic spines. Cell Tissue Res. 2020;382(1):185–99. DOI: https://doi.org/10.1007/s00441-020-03226-5 10. Fominova UN, Gurina OI, Shepeleva II, et al. [Brain-derived Neurotrophic Factor: Structure and Interaction with Receptors]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2018;(4):64–72. (In Russ.) 11. Gulyaeva NV. Interplay between Brain BDNF and Glutamatergic Systems: A Brief State of the Evidence and Association with the Pathogenesis of Depression. Biochemistry (Mosc). 2017;82(3):301–7. DOI: https://doi.org/10.1134/S0006297917030087 12. Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology. 2008;33(1):73–83. DOI: https://doi.org/10.1038/sj.npp.1301571 13. Bjоrkholm C, Monteggia L. M. BDNF – a key transducer of antidepressant effects. Neuropharmacology. 2016;102:72–9. DOI: https://doi.org/10.1016/j.neuropharm.2015.10.034 14. Favalli G, Li J, Belmonte-de-Abreu P, et al. The role of BDNF in the pathophysiology and treatment of schizophrenia. J Psychiatr Res. 2012;46(1):1–11. DOI: https://doi.org/10.1016/j.jpsychires.2011.09.022 15. Sokoloff P, Guillin O, Diaz J, et al. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: implications for neurodevelopmental psychiatric disorders. Neurotox Res. 2002;4(7–8):671–8. DOI: https://doi.org/10.1080/1029842021000045499 16. Guillin O, Demily C, Thibaut F. Brain-derived neurotrophic factor in schizophrenia and its relation with dopamine. Int Rev Neurobiol. 2007;78:377–95. DOI: https://doi.org/10.1016/S0074-7742(06)78012-6 17. Bosse KE, Maina FK, Birbeck JA, et al. Aberrant striatal dopamine transmitter dynamics in brain-derived neurotrophic factor-deficient mice. J Neurochem. 2012;120(3):385–95. DOI: https://doi.org/10.1111/j.1471-4159.2011.07531.x 18. Hempstead BL. Brain-derived neurotrophic factor: three ligands, many actions. Trans Am Clin Climatol Assoc. 2015;126:9–19. PMID: 26330656 19. Zhang X-Y, Liu F, Chen Y, et al. Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation. Neural Regen Res. 2020;15(6):1066–70. DOI: https://doi.org/10.4103/1673-5374.270314 20. Wang M, Xie Y, Qin D. Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases. Brain Res Bull. 2021;166:172–84. DOI: https://doi.org/10.1016/j.brainresbull.2020.11.005 21. Martinelli S, Anderzhanova EA, Bajaj T, et al. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nat Commun. 2021;12(1):4643. DOI: https://doi.org/10.1038/s41467-021-24810-5 22. Colucci-D'Amato L, Speranza L, Volpicelli F. Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. Int J Mol Sci. 2020;21(20):7777. DOI: https://doi.org/10.3390/ijms21207777 23. Martinowich K, Hattori D, Wu H, et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003;302(5646):890–3. DOI: https://doi.org/10.1126/science.1090842 24. Boulle F, van den Hove DLA, Jakob SB, et al. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry. 2012;17(6):584–96. DOI: https://doi.org/10.1038/mp.2011.107 25. Zheleznyakova GY, Cao H, Schioth HB. BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis. Behav Brain Funct. 2016;12:17. DOI: https://doi.org/10.1186/s12993-016-0101-4 26. Keifer J, Zheng Z, Ambigapathy G. A MicroRNA-BDNF Negative Feedback Signaling Loop in Brain: Implications for Alzheimer's Disease. Microrna. 2015;4(2):101–8. DOI: https://doi.org/10.2174/2211536604666150813152620 27. Esvald E-E, Tuvikene J, Sirp A, et al. CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons. J Neurosci. 2020;40(7):1405–26. DOI: https://doi.org/10.1523/JNEUROSCI.0367-19.2019 28. Tamura S, Suzuki H, Hirowatari Y, et al. Release reaction of brain-derived neurotrophic factor (BDNF) through PAR1 activation and its two distinct pools in human platelets. Thromb Res. 2011;128(5):e55–61. DOI: https://doi.org/10.1016/j.thromres.2011.06.002 29. Chacón-Fernández P, Säuberli K, Colzani M, et al. Brain-derived Neurotrophic Factor in Megakaryocytes. J Biol Chem. 2016;291(19):9872–81. DOI: https://doi.org/10.1074/jbc.M116.720029 30. Aatonen MT, Ohman T, Nyman TA, et al. Isolation and characterization of platelet-derived extracellular vesicles. J Extracell Vesicles. 2014;3:24692. DOI: https://doi.org/10.3402/jev.v3.24692 31. Mustapic M, Eitan E, Werner JK Jr, et al. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes. Front Neurosci. 2017;11:278. DOI: https://doi.org/10.3389/fnins.2017.00278 32. Gelle T, Samey RA, Plansont B, et al. BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2021;109:110229. DOI: https://doi.org/10.1016/j.pnpbp.2020.110229 33. Weaver KR, Mustapic M, Kapogiannis D, Henderson WA. Neuronal-enriched extracellular vesicles in individuals with IBS: A pilot study of COMT and BDNF. Neurogastroenterol Motil. 2022;34(1):e14257. DOI: https://doi.org/10.1111/nmo.14257 34. Pandey GN, Dwivedi Y, Rizavi HS, et al. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(4):645–51. DOI: https://doi.org/10.1016/j.pnpbp.2010.03.003 35. Lee B-H, Kim Y-K. BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide. J Affect Disord. 2010;125(1–3):369–73. DOI: https://doi.org/10.1016/j.jad.2010.01.074 36. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett. 2002;328(3):261–4. DOI: https://doi.org/10.1016/s0304-3940(02)00529-3 37. Sartorius A, Hellweg R, Litzke J, et al. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry. 2009;42(6):270–6. DOI: https://doi.org/10.1055/s-0029-1224162 38. Klein AB, Williamson R, Santini MA, et al. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol. 2011;14(3):347–53. DOI: https://doi.org/10.1017/S1461145710000738 39. Luo H-Y, Rahman M, Bobrovskaya L, Zhou X-F. The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke. Neurotox Res. 2019;36(1):49–57. DOI: https://doi.org/10.1007/s12640-019-00022-0 40. Wang H-Y, Crupi D, Liu J, et al. Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte. J Neurosci. 2011;31(30):11044–54. DOI: https://doi.org/10.1523/JNEUROSCI.2125-11.2011 41. Du Y, Wu H-T, Qin X-Y, et al. Postmortem Brain, Cerebrospinal Fluid, and Blood Neurotrophic Factor Levels in Alzheimer's Disease: A Systematic Review and Meta-Analysis. J Mol Neurosci. 2018;65(3):289–300. DOI: https://doi.org/10.1007/s12031-018-1100-8 42. Gadad BS, Vargas-Medrano J, Ramos EI, et al. Altered levels of interleukins and neurotrophic growth factors in mood disorders and suicidality: an analysis from periphery to central nervous system. Transl Psychiatry. 2021;11(1):341. DOI: https://doi.org/10.1038/s41398-021-01452-1 43. Erbay LG, Karlıdag R, Oruc M, et al. Association of BDNF/TrkB and NGF/TrkA Levels in Postmortem Brain with Major Depression and Suicide. Psychiatr Danub Winter. 2021;33(4):491–8. DOI: https://doi.org/10.24869/psyd.2021.491 44. Eisen RB, Perera S, Bawor M, et al. Exploring the association between serum BDNF and attempted suicide. Sci Rep. 2016;6:25229. DOI: https://doi.org/10.1038/srep25229 45. Fusar-Poli L, Aguglia A, Amerio A, et al. Peripheral BDNF levels in psychiatric patients with and without a history of suicide attempt: A systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110342. DOI: https://doi.org/10.1016/j.pnpbp.2021.110342 46. Lang UE, Hellweg R, Seifert F, et al. Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity. Biol Psychiatry. 2007;62(5):530–5. DOI: https://doi.org/10.1016/j.biopsych.2007.01.002 47. Zhang XY, Liang J, Chen DC, et al. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology (Berl). 2012;222(2):277–84. DOI: https://doi.org/10.1007/s00213-012-2643-y 48. Rosa RF, Ugolini-Lopes MR, Gandara APR, et al. Cognitive dysfunction and serum levels of brain-derived neurotrophic factor (BDNF) in primary anti-phospholipid syndrome (PAPS). Rheumatology (Oxford). 2021;60(1):179–87. DOI: https://doi.org/10.1093/rheumatology/keaa252 49. Anders QS, Ferreira LVB, de Melo Rodrigues LC, Nakamura-Palacios EM. BDNF mRNA Expression in Leukocytes and Frontal Cortex Function in Drug Use Disorder. Front Psychiatry. 2020;11:469. DOI: https://doi.org/10.3389/fpsyt.2020.00469 50. Stenz L, Zewdie S, Laforge-Escarra T, et al. BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues. Neurosci Res. 2015;91:1–7. DOI: https://doi.org/10.1016/j.neures.2014.10.003 51. Nassan M, Veldic M, Winham S, et al. Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder. J Affect Disord. 2020;267:96–102. DOI: https://doi.org/10.1016/j.jad.2020.02.002 52. Hsieh M-T, Lin C-C, Lee C-T, Huang T-L. Abnormal Brain-Derived Neurotrophic Factor Exon IX Promoter Methylation, Protein, and mRNA Levels in Patients with Major Depressive Disorder. J Clin Med. 2019;8(5):568. DOI: https://doi.org/10.3390/jcm8050568 53. D'Addario C, Dell'Osso B, Galimberti D, et al. Epigenetic modulation of BDNF gene in patients with major depressive disorder. Biol Psychiatr. 2013;73:e6–e7. DOI: https://doi.org/10.1016/j.biopsych.2012.07.009 54. Begliuomini S, Lenzi E, Ninni F, et al. Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm. J Endocrinol. 2008;197(2):429–35. DOI: https://doi.org/10.1677/JOE-07-0376 55. Molendijk ML, Haffmans JPM, Bus BAA, et al. Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. PLoS One. 2012;7(11):e48046. DOI: https://doi.org/10.1371/journal.pone.0048046 56. Uzbekov MG, Gurovich IYa, Ivanova SA. [Potentsial'nye biomarkery psikhicheskikh zabolevanii v aspekte sistemnogo podkhoda]. Sotsial'naya i klinicheskaya psikhiatriya. 2016;2(1):77–94. (In Russ.) 57. Woods AG, Wormwood KL, Iosifescu DV, et al. Protein Biomarkers in Major Depressive Disorder: An Update. Adv Exp Med Biol. 2019;1140:585–600. DOI: https://doi.org/10.1007/978-3-030-15950-4_35 58. Gao L, Zhang Y, Sterling K, Song W. Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential. Transl Neurodegener. 2022;11(1):4. DOI: https://doi.org/10.1186/s40035-022-00279-0 59. Pavlova OV, Murashko AA, Andryushchenko NV, et al. [Razrabotka kolichestvennogo immunofermentnogo analiza neirotroficheskogo faktora mozga na osnove rekombinantnogo antigena]. Neirokhimiya. 2023;40(1):86–91. DOI: https://doi.org/10.31857/S1027813323010156 60. Han D, Sun D, Xiu M, et al. Association between the improvement in depressive symptoms and serum BDNF levels in drug-naive first episode patients with schizophrenia: A longitudinal follow-up. Psychoneuroendocrinology. 2021;133:105392. DOI: https://doi.org/10.1016/j.psyneuen.2021.105392 61. Chiou Y-J, Huang T-L. Brain-derived neurotrophic factor (BDNF) and bipolar disorder. Psychiatry Res. 2019;274:395–9. DOI: https://doi.org/10.1016/j.psychres.2019.02.051

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM