Brain-derived neurotrophic factor as a potential diagnostic biomarker of mental disorders
Suggested citation:
Pavlova OV, Gurina OI, Shport SV, et al. [Brain-derived neurotrophic factor as a potential diagnostic biomarker of mental disorders]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2023;(2):76-85. Russian
In this scientific review, in order to investigate the possibility of using the levels of brain-derived neurotrophic factor in peripheral blood as a diagnostic biomarker of mental diseases, including depressive disorders, an analysis of Russian and foreign publications related to this topic was carried out. Attention is paid to the synthesis of brain-derived neurotrophic factor and its regulation in the central nervous system, the functional significance of this protein, its sources in peripheral blood are determined, and correlations of the content of this protein in the central nervous system and on the periphery are revealed.
Keywords mental disorders; biomarker; the brain-derived neurotrophic factor; BDNF; correlation of central and peripheral BDNF levels
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