Inflammation and disruption of the “Lipid peroxidation – Antioxidant protection” system in the mechanisms of the course of posttraumatic stress disorder

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Ozornin AS, Sakharov AV. [Inflammation and disruption of the “Lipid peroxidation – Antioxidant protection” system in the mechanisms of the course of posttraumatic stress disorder]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2024;(4):92-102. Russian

Abstract

In the scientific review, in order to analyze and systematize the literature data on the role of markers of inflammation and the functioning of the “Lipid peroxidation – Antioxidant protection” system in post-traumatic stress disorder, articles for the period 1990–2023 were searched in the PubMed and e-Library.ru. The review provides information on the increased content of peripheral cytokines and the intensification of lipoperoxidation processes with a weakening of the enzymatic component of antioxidant protection. The mechanisms of occurrence of these disorders are considered. The effects of neuroinflammation and oxidative stress on morpho-functional disorders of the brain are described. The presented scientific results require a more detailed assessment to establish new neurobiological and pathogenetic functions of neuroinflammation in post-traumatic stress disorder.

Keywords post-traumatic stress disorder; inflammation; cytokines; oxidative stress

References

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