Cytokines and their role in the pathogenesis, clinical heterogeneity of schizophrenia and response to antipsychotic therapy

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Ivanova SA, Boyko AS, Bokhan NA. [Cytokines and their role in the pathogenesis, clinical heterogeneity of schizophrenia and response to antipsychotic therapy]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2024;(3):81-91. Russian

Abstract

In this scientific review, in order to systematize contemporary ideas about the potential role of cytokines in the pathogenesis of schizophrenia, their changes during the first psychotic episode and chronic schizophrenia, features of the content in various types of course, leading clinical symptoms and duration of the disease, an analysis of Russian and foreign studies of the past 15 years on electronic information resources (Elsevier library, PubMed, NCBI, Google Scholar, eLIBRARY) has been carried out. Particular attention has been paid to the influence of antipsychotics used for pharmacotherapy on the dynamics of cytokines. The participation of immunoinflammatory markers in response to antipsychotic therapy and the development of drug-induced side effects of psychopharmacotherapy have been analyzed. In conclusion, the main prospects and directions for further research are presented.

Keywords schizophrenia; cytokines; antipsychotic therapy

References

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