Risperidone for comprehensive treatment of patients with chronic refractory obsessive-phobic disorders
Suggested citation:
Yastrebov DV, Zakharova KV, Marachev MP. [Risperidone for comprehensive treatment of patients with chronic refractory obsessive-phobic disorders]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2015;(5):92-100. Russian
Continuous and protracted treatmentresistant anxious and obsessive states are linked to a wide set of problems with diagnostics, its course and treatments. However the attitude towards this subject of clinical attention seems to be a sort of casual. The increase of interest to these disorders may not only improve understandings of connexions with comorbid psychotic states as far as with certain personality disorders but do define optimal therapeutic approach. As a result of the study of efficacy of atypical antipsychotic «Risperidon-Organica» in a fixed dose of 2 mg a day as a part of complex therapy of resistant anxiety and obsessive disorders in combination with SSRI agents, the improvement was achieved in 73% of patients who failed to respond previous treatment. The advantage of this method is the equivalence of the effect observed in all syndromes’ decrease in a period of two–four weeks from the therapy beginning.
1. Goodman W.K., Price L.H., Rasmussen S.A., Delgado P.L. et al. Efficacy of fluvoxamine in obsessive-compulsive disorder. A doubleblind comparison with placebo // Arch. Gen. Psychiatry. 1989. Vol. 46, N 1. P. 36-44. 2. Saxena S., Wang D., Bystritsky A., Baxter L.R. Jr. Risperidone augmentation of SRI treatment for refractory obsessive-compulsive disorder // J. Clin. Psychiatry. 1996. Vol. 57, N 7. P. 303-306. 3. Stein D.J., Bouwer C., Hawkridge S., Emsley R. A. Risperidone augmentation of serotonin reuptake inhibitors in obsessive-compulsive and related disorders // J. Clin. Psychiatry. 1997. Vol. 58, N 3. P. 119-122. 4. Fitzgerald K.D., Stewart C.M., Tawile V., Rosenberg D.R. Risperidone augmentation of serotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder // J. Child Adolesc. Psychopharmacol. 1999. Vol. 9, N 2. P. 115-123. 5. Захарова К.В., Ястребов Д.В. Роль антипсихотических препаратов в лечении обсессивно-компульсивного расстройства. Перспективы использования рисперидона // Обозр. психиатрии и мед. психол. 2013. № 3. С. 70-77. 6. Bland R.C., Newman S.C., Orn H. Schizophrenia: lifetime comorbidity in a community sample // Acta Psychiatr. Scand. 1987. Vol. 75. P. 383-391 7. Bermanzohn P.C., Porto L., Siris S.G. et al. Hierarchy, reductionism, and "comorbidity" in the diagnosis of schizophrenia // Schizophrenia and Comorbid Conditions: Diagnosis and Treatment. Washington DC : American Psychiatric Press, 2001. P. 1-30. 8. Bermanzohn P.C., Porto L., Siris S.G. et al. Hierarchical diagnosis in chronic schizophrenia: a clinical study of cooccurring syndromes // Schizophr. Bull. 2000. Vol. 26. P. 519-527. 9. Berman I., Kalinowski A., Berman S.M. et al. Obsessive and compulsive symptoms in chronic schizophrenia // Compr. Psychiatry. 1995. Vol. 36. P. 6-10. 10. Zohar J. Is there room for a new diagnostic subtype - the schizoobsessive subtype? // CNS Spectrums. 1997. Vol. 2, N 3. P. 49-50. 11. Poyurovsky M. Schizo-Obsessive Disorder. N.Y. : Cambridge University Press, 2013. 236 p. 12. Poyurovsky M., Hermesh H., Weizman A. Fluvoxamine treatment in clozapine-induced obsessive-compulsive symptoms in schizophrenic patients // Clin. Neuropharmacol. 1996. Vol. 19. P. 305-313. 13. Rodriguez C.I., Corcoran C., Simpson H.B. Diagnosis and treatment of a patient with both psychotic and obsessive-compulsive symptoms // Am. J. Psychiatry. 2010. Vol. 167. P. 754-761. 14. Семке В.Я., Платонов Д.Г., Новиков В.Э. Труднокурабельные больные в пограничной психиатрии. Томск, 2010. 196 с. 15. Baker R.W., Bermanzohn P.C., Wirsching D.A. et al. Obsessions, compulsions clozapine and risperidone // CNS Spectrums. 1997. Vol. 2, N 3. P. 26-36. 16. Baker R. W., Chengappa K. N. R., Baird J. W. et al. Emergence of obsessive-compulsive symptoms during treatment with clozapine // J. Clin. Psychiatry. 1992. Vol. 53. P. 439-441. 17. Ghaemi S.N., Zarate C.A., Popli A.P. et al. Is there relationship between clozapine and obsessive compulsive disorder? A retrospective chart review // Compr. Psychiatry. 1995. Vol. 36. P. 267-270. 18. Morrison D., Clark. D., Goldfarb E. et al. Worsening of obsessivecompulsive symptoms following treatment with olanzapine // Am. J. Psychiatry. 1998. Vol. 155. P. 855. 19. Hiemke C., Weigmann H., Hartter S. et al. Elevated levels of clozapine in serum after addition of fluvoxamine // J. Clin. Psychopharmacol. 1994. Vol. 14. P. 279-281. 20. Margetis B. Aggravation of schizophrenia by clomipramine in a patient with comorbid obsessive-compulsive disorder // Psychopharmacol. Bull. 2008. Vol. 41. P. 9-11. 21. Poyurovsky M. Obsessive-compulsive symptoms in schizophrenia: clinical characterization and treatment // Clinical ObsessiveCompulsive Disorders in Adults and Children / eds R. Hudak, D.D. Dougherty. Cambridge University Press, 2011. P. 71-91. 22. Poyurovsky M., Weizman A. Intravenous clomipramine for a schizophrenic patient with obsessive-compulsive symptoms // Am. J. Psychiatry. 1998. Vol. 155. P. 1993. 23. Reznik I., Sirota P. Obsessive and compulsive symptoms in schizophrenia: a randomized controlled trial with fluvoxamine and neuroleptics // J. Clin. Psychopharmacol. 2000. Vol. 20. P. 410-416. 24. Green A.I., Canuso C.M., Brenner M.J., Wojcik J.D. Detection and management of comorbidity in patients with schizophrenia // Psychiatr. Clin. North Am. 2003. Vol. 26. P. 115-139. 25. de Haan L., Linszen D. H., Gorsira R. Clozapine and obsessions in patients with recent onset schizophrenia and other psychotic disorders // J. Clin. Psychiatry. 1999. Vol. 60. P. 364-365. 26. de Haan L., Beuk N., Hoogenboom B. Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent-onset schizophrenia or related disorders // J. Clin. Psychiatry. 2002. Vol. 63. P. 104-107. 27. Ястребов Д.В. Терапия обсессивных и тревожных расстройств у больных с непсихотическими формами шизофрении // Психиатрия и психофармакотер. 2011. Т. 13, № 4. С. 38-47. 28. Khullar A., Chue P., Tibbo P. Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychoticinduced OCS // J. Psychiatry Neurosci. 2001. Vol. 26. P. 55-59. 29. Alevizos B., Lykouras L., Zervas I. M. Risperidone-induced obsessivecompulsive symptoms: a series of six cases // J. Clin. Psychopharmacol. 2002. Vol. 22. P. 461-467. 30. Mahendran R. Obsessive-compulsive symptoms with risperidone // J. Clin. Psychiatry. 1999. Vol. 60. P. 261-263. 31. Аведисова А.С., Ястребов Д.В. Шизофрения и биполярное расстройство / Вопросы клиники и терапии. М. : Перо, 2013.
DOI: http://dx.doi.org/10.24411/1560-957X-2015-1%25x
Article Metrics
Metrics powered by PLOS ALM