Chemically induced models of Alzheimer's disease: current approaches and new perspectives

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Ochneva AG, Gurin PI, Ochigova ED, et al. [Chemically induced models of Alzheimer's disease: current approaches and new perspectives]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2024;(5):78-91. Russian

Abstract

In this scientific review aiming to explore and summarize the evidence on chemical translational models of Alzheimer's disease, 88 articles were analyzed. Alzheimer's disease (AD) is a progressive neurodegenerative disease. Recent advances in understanding the pathophysiologic mechanisms of AD and other cognitive disorders have suggested new approaches to developing treatments. These advances have been driven to some extent by the use of translational models. Various types of animal models have been used in research, including chemical models that are based on the administration of drugs that cause cognitive decline. This review describes the main pathophysiologic mechanisms of AD and the existing chemical translational models of AD, which are central to understanding the pathogenesis of the disease and evaluating the potential of new therapeutic approaches. Additionally, experimental data for a novel new approach in rodent models of AD are presented.

Keywords dementia; Alzheimer's disease; translational models; beta-amyloid

References

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