Neurocognitive characteristics in people with post-traumatic stress disorder: comorbidity or a consequence of stress?

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Shipkova KM, Shport SV, Galanina NA. [Neurocognitive characteristics in people with post-traumatic stress disorder: comorbidity or a consequence of stress?]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2025;(4):35-43. Russian

Abstract

This scientific article provides an analytical review of research on this topic in order to examine the neurocognitive status of people with post-traumatic stress disorder and the specifics of structural changes in the brain as a result of traumatic stress. The article evaluates the procedural, dynamic and substantive aspects of cognitive dysfunction, as well as analyzes the mechanisms of cognitive and regulatory rigidity. The mechanisms of formation of memory deficit and possible causes of disturbance of event chronotope in autobiographical memory are discussed. Macro- and microstructural changes in the brain as a consequence of chronic stress are described. Further directions of neurobiological and neuropsychological research are outlined. The importance of studying the substantive aspects of cognitive functioning and neurocognitive predisposition to stress is substantiated.

Keywords posttraumatic stress disorder; cognitive decline; neurocognition; memory disorders; cognitive flexibility; regulatory flexibility; trauma

References

1. Ressler KJ, Berretta S, BolshakovVY, et al. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022;18(5):273–88. DOI: 10.1038/s41582-022-00635-8 2. Burback L, Brémault-Phillips S, Nijdam MJ, et al. Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review. Curr Neuropharmacol. 2024;22(4):557–635. DOI: 10.2174/1570159X21666230428091433 3. Sukiasyan SG. [Posttraumatic or Pеritraumatic Disorders: A Diagnostic Dilemma]. Sovrem. ter. psih. rasstrojstv [Current Therapy of Mental Disorders]. 2022;(3):3–13. (In Russ.) DOI: 10.21265/PSYPH.2022.69.67.001 4. Gadisov TG, Fastovtcov GA, Zacharova NM. [The effectiveness of psychotherapeutic methods of treatment of post-traumatic stress disorder: a systematic review of meta-analyses]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2025;(1):82–93. (In Russ.) 5. Janssen PGJ, van Est LAC, Hilbink M, et al. Social cognitive performance in posttraumatic stress disorder: A meta-analysis. J Affect Disord. 2022;297:35–44. DOI: 10.1016/j.jad.2021.09.082 6. Mureșanu IA, Grad DA, Mureșanu DF, et al. Evaluation of post-traumatic stress disorder (PTSD) and related comorbidities in clinical studies. J Med Life. 2022;15(4):436–42. DOI: 10.25122/jml-2022-0120 7. Loignon A, Ouellet MC, Belleville G. A Systematic Review and Meta-analysis on PTSD Following TBI Among Military/Veteran and Civilian Populations. J Head Trauma Rehabil. 2020;35(1):E21. DOI: 10.1097/HTR.0000000000000514 8. Jellestad L, Vital NA, Malamud J, et al. Functional impairment in Posttraumatic Stress Disorder: A systematic review and meta-analysis. J Psychiatr Res. 2021;136:14–22. DOI: 10.1016/j.jpsychires.2021.01.039 9. Vyas K, Murphy D, Greenberg N. Cognitive biases in military personnel with and without PTSD: a systematic review. J Ment Health. 2023;32(1):248–59. DOI: 10.1080/09638237.2020.1766000 10. American Psychiatric Association. DSM-5 Task Force. Diagnostic and Statistical Manual of Mental Disorders: DSM-5™ (5th ed.). American Psychiatric Publishing, Inc.; 2013. 991 p. DOI: 10.1176/appi.books.9780890425596 11. Kredlow AM, Fenster RJ, Laurent ES, et al. Prefrontal cortex, amygdala, and threat processing: implications for PTSD. Neuropsychopharmacol. 2022;47(1):247–59. DOI: 10.1038/s41386-021-01155-7 12. Koopowitz SM, Maré KT, Zar HJ, et al. The neurocognitive profile of post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and PTSD with comorbid MDD. Brain Behav. 2021;11(4):e01950. DOI: 10.1002/brb3.1950 13. Nijdam MJ, Vermetten E, McFarlane AC. Toward staging differentiation for posttraumatic stress disorder treatment. Acta Psychiatr Scand. 2023;147(1):65–80. DOI: 10.1111/acps.13520 14. Diminich ED, Clouston SAP, Kranidis A, et al. Chronic Posttraumatic Stress Disorder and Comorbid Cognitive and Physical Impairments in World Trade Center Responders. J Trauma Stress. 2021;34(3):616–27. DOI: 10.1002/jts.22631 15. An Y, Zhao J, Shi J, Hou WK. Network analysis of posttraumatic stress disoder symptoms among adolescent survivors of a major disaster in China. Psychol Trauma. 2021;14(1):132–40. DOI: 10.1037/tra0001053 16. Martin MM, Rubin RB. A new measure of cognitive flexibility. Psychol Rep. 1995;76:623–26. DOI: 10.2466/pr0.1995.76.2.623 17. Schultebraucks K, Ben-Zion Z, Admon R, et al. Assessment of early neurocognitive functioning increases the accuracy of predicting chronic PTSD risk. Mol Psychiatry. 2022;27(4):2247–54. DOI: 10.1038/s41380-022-01445-6 18. Prajapati SK, Krishnamurthy S. Development and treatment of cognitive inflexibility in sub-chronic stress-re-stress (SRS) model of PTSD. Pharmacol Rep. 2021;73(2):464–79. DOI: 10.1007/s43440-020-00198-9 19. Franks KH, Bransby L, Saling MM, Pase MP. Association of Stress with Risk of Dementia and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2021;82(4):1573–90. DOI: 10.3233/JAD-210094 20. Roberts AL, Liu J, Lawn RB, et al. Association of Post-traumatic Stress Disorder With Accelerated Cognitive Decline in Middle-aged Women. JAMA Netw Open. 2022;5(6):e2217698. DOI: 10.1001/jamanetworkopen.2022.17698 21. Prieto S, Moody JN, Valerio KE, Hayes JP. Posttraumatic stress disorder symptom severity is associated with reduced Montreal Cognitive Assessment scores in a sample of Vietnam War Veterans. J Trauma Stress. 2022;35(4):1282–90. DOI: 10.1002/jts.22830 22. Bonanno GA, Burton CL. Regulatory flexibility: an individual differences perspective on coping and emotion regulation. Perspect Psychol Sci. 2013;8(6):591–612. DOI: 10.1177/1745691613504116 23. Haim-Nachum S, Levy-Gigi E. The Tension Between Cognitive and Regulatory Flexibility and Their Associations With Current and Lifetime PTSD Symptoms. Front. Psychol. 2021;12:615289. DOI: 10.3389/fpsyg.2021.615289 24. Daneshvar S, Basharpoor S, Shafiei M. Self-compassion and cognitive flexibility in trauma-exposed individuals with and without PTSD. Curr Psychol. 2022;41(4):2045–52. DOI: 10.1007/s12144-020-00732-1 25. Pitts BL, Eisenberg M., Bailey H, et al. PTSD is associated with impaired event processing and memory for everyday events. Cogn Res Princ Implic. 2022;7(1):35. DOI: 10.1186/s41235-022-00386-6 26. Moradi AR, Piltan M, Choobin MH, et al. Proof of Concept for the Autobiographical Memory Flexibility (MemFlex) Intervention for Posttraumatic Stress Disorder. Clin Psychol Sci. 2021;9(4):686–98. DOI: 10.1177/2167702620982576 27. Piltan M, Moradi AR, Choobin MH, et al. Impaired Autobiographical Memory Flexibility in Iranian Trauma Survivors With Posttraumatic Stress Disorder. Clin Psychol Sci. 2021;9(2):294–301. DOI: 10.1177/2167702620953637 28. Cvetkova LS. Afaziologija: sovremennye problemy i puti ih reshenija. Moscow; 2002. 640 p. (In Russ.) 29. Faustova AG. [“Difficult to remember and impossible to forget”: Mechanisms of functioning of traumatic memory]. Lichnost' v menjajushhemsja mire: zdorov'e, adaptacija, razvitie [Personality in a Changing World: Health, Adaptation, Development]. 2024;12(3):193–206. (In Russ.) DOI: 10.23888/humJ2024123193-206 30. Sorokko EA. [The Stroop effect in psychological trauma: a review of research]. Mir nauki. Pedagogika i psihologija [World of Science. Pedagogy and psychology]. 2023;11(3):64PSMN323. (In Russ.) 31. Günak MM, Billings J, Carratu E, et al. Post-traumatic stress disorder as a risk factor for dementia: systematic review and meta-analysis. Br J Psychiatry. 2020;217(5):600–8. DOI: 10.1192/bjp.2020.150 32. Rozanov IA, Bulygina VG, Gvozdeva AA. [Post-traumatic stress disorder and suicidal behavior: common factorsof etiology and pathogenesis]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2025;(1):94–105. (In Russ.) 33. Rosen R, Shao Y, Zhang Q, et al. Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms. Int J Environ Res Public Health. 2022;19(6):3440. DOI: 10.3390/ijerph19063440 34. Sobczak S, Olff M, Rutten B, et al. Comorbidity rates of Posttraumatic Stress Disorder in dementia: a systematic literature review. Eur J Psychotraumatol. 2021;12(1):1883923. DOI: 10.1080/20008198.2021.1883923 35. Rajkumar RP. Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review. Biomedicines. 2023;11(5):1465. DOI: 10.3390/biomedicines11051465 36. Deri Y, Clouston SAP, DeLorenzo C, et al. Selective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment. Alzheimers Dement. 2021;13(1):e12165. DOI: 10.1002/dad2.12165 37. Clouston SAP, Hall CB, Kritikos M, et al. Cognitive impairment and World Trade Centre-related exposures. Nat Rev Neurol. 2022;18(2):103–16. DOI: 10.1038/s41582-021-00576-8 38. Marcolini S, Rojczyk P, Seitz-Holland J, et al.; Department of Defense Alzheimer’s Disease Neuroimaging Initiative. Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans. J Alzheimers Dis. 2023;95(4);1427–48. DOI: 10.3233/JAD-221304 39. Kritikos M, Clouston SAP, Huang C, et al. Cortical complexity in world trade center responders with chronic posttraumatic stress disorder. Translational Psychiatry. 2021;11(1):597. DOI: 10.1038/s41398-021-01719-7 40. Kang JI., Mueller SG, Wu GWY, et al. Effect of combat exposure and posttraumatic stress disorder on telomere length and amygdala volume. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(7):678–87. DOI: 10.1016/j.bpsc.2020.03.007 41. Brown EM, Salat DH, Milberg WP, et al. Accelerated longitudinal cortical atrophy in OEF/OIF/OND veterans with severe PTSD and the impact of comorbid TBI. Hum Brain Mapp. 2022;43(12):3694–705. DOI: 10.1002/hbm.25877 42. Lee MS, Anumagalla P, Pavuluri MN. Individuals with the post-traumatic stress disorder process emotions in subcortical regions irrespective of cognitive engagement: a meta-analysis of cognitive and emotional interface. Brain Imaging Behav. 2021;15(2):941–57. DOI: 10.1007/s11682-020-00303-9 43. Ispolatova EN, Tsukarzi EE. [Post-Traumatic Stress Disorder: Morphological Substrates, Neural Networks and Transcranial Magnetic Stimulation Potential Benefits]. Sovrem Ter Psih Rasstrojstv [Current Therapy of Mental Disorders]. 2022;3:45–9. (In Russ.) DOI: 10.21265/PSYPH.2022.78.73.005

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