The concept of endophenotype: a new approach to the study of pathogenesis of affective disorders (analytical review). Part 1
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Vazagaeva TI, Akhapkin RV. [The concept of endophenotype: a new approach to the study of pathogenesis of affective disorders (analytical review). Part 1]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2013;(3):22-31. Russian
The article describes the modern approaches to the study of etiology and pathogenesis of affective disorders, characterized by genetic and phenotypic heterogeneity, based on the identification of diagnostic and prognostic biomarkers and endophenotypes. Provides data of foreign literature about neuropsychological and cognitive candidates-endophenotypes occurring in family and twin observations with the involvement of molecular-genetic researches. Analyzes the validity of use as endophenotypes individual neurocognitive indicators in patients with affective disorders, demonstrated in patients and their healthy relatives with increasing extent in proportion to the increase genetic relationship and is closely associated with polymorphisms of genes.
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DOI: http://dx.doi.org/10.24411/1560-957X-2013-11332
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