The concept of endophenotype: a new approach to the study of pathogenesis of affective disorders (analytical review). Part 2
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Vazagaeva TI, Akhapkin RV. [The concept of endophenotype: a new approach to the study of pathogenesis of affective disorders (analytical review). Part 2]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2013;(4):37-48. Russian
The paper provides a systematic review of outcomes of neurobiological studies geared towards a quest for candidate-endophenotypes in affective disorders that mediate between genetic factors and clinical presentations of disease. Described are neurovizualizing (structural and functional) and neurochemical disorders revealed in affective pathology such as hyperintensity of white matter, enhanced activation of amygdala and orbitofrontal cortex, pathological changes in neurotrophic factors and concentrations of various neurochemical substrates and neurotransmitters in distinct areas of the brain and others, which reflect in a specific and demonstrable manner the ethiopathogenetic mechanisms underlying the development of disease process.
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DOI: http://dx.doi.org/10.24411/1560-957X-2013-11345
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