The dynamics of functioning level in the process of Tiapride therapy of confusional states in cases of cerebro-organic pathology in old age

Full Text:
Read (RU)

Suggested citation:

Kruglov LS, Belencova TM, Belencova VS, et al. [The dynamics of functioning level in the process of Tiapride therapy of confusional states in cases of cerebro-organic pathology in old age]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2014;(2):80-84. Russian

Abstract

Psychical confusion complicates the process of care and treatment of elder patients, especially those suffering from dementia and often becomes a reason for their hospitalization in a psychiatric dispensary as well. Though this problem has been subjected to study for several decades, questions of effective therapy of the states alike still remain undeveloped enough. For all this, data concerning the influence of treatment with up-to-date antipsychotics on patients, functioning suffering from these disorders are not in fact available. The present article refers to the analysis of results of Tiapride usage as an up-to-date neuroleptic in brain organic diseases of elders with phenomena of acute psychical confusion. 69 patients suffering from a.m. disorders were studied Results of treatment in 3 subgroups were compared: in one of which Haloperidol was applied in small doses, in another – Tiapride and in the third – a neurometabolic, vitaminic and vasoactive therapy was mainly applied. Results obtained showed that the usage of psychotropics in states of acute confusion as a rule appears to be inevitable, Tiapride therapy being effective enough and more safe than the treatment with a standard neuroleptic Haloperidol. Tiapride usage turns out to be more expedient in connection with raisingm the level of patients, functioning as well.

References

1. Авербух Е.С. Расстройства психической деятельности в позднем возрасте. – Л.: Медицина, 1969. – 284 с. 2. Круглов Л.С. Сосудистые заболевания головного мозга с психоорганическим синдромом у пациентов позднего возраста (исследование клинико-социальных характеристик, их значения и динамики в процессе терапии): Автореф. дис. … д-ра мед. наук. – СПб., 2007. – 38 с. 3. Точилов В.А., Протальская А.Г. Нейролептики – производные замещенных бензамидов в психиатрической практике // Соц. и клин. психиатрия. – 1998. – № 3. – С. 137–145. 4. Штернберг Э.Я. Особые формы психозов позднего возраста // Руководство по психиатрии / Под ред. А.С. Тиганова. – М.: Медицина, 1999. – Т. 2. – С. 117–128. 5. Hschieh T.T., Fong T.G., Marcantonio E.R. et al. Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence // J. Gerontol. Biol. Med. Sci. – 2008. – Vol. 63, N 7. – P. 764–772. 6. Maldonado J.R. Pathoetiological model of delirium: comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment // Crit. Care Clin. – 2008. – Vol. 24, N 4. – P. 789–856. 7. Seitz D.P., Gill S.S., van Zyl L.T. Antipsychotics in the treatment of delirium: a systematic review. – 2007. – Vol. 68, N 1. – P. 11–21. 8. Willi J. Delirium, Dammerzustand und Verwirttheit bei korperlich Kranken // M. Bleuler Akute psych. Begleitersch. Korperl. Krankheiten. – Stuttgart, 1968. – S. 27–128.



DOI: http://dx.doi.org/10.24411/1560-957X-2014-1%25x

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM