The effect of risperidone on the neurocognitive deficit in schizophrenia
Suggested citation:
Vazagaeva TI. [The effect of risperidone on the neurocognitive deficit in schizophrenia]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2015;(2):76-81. Russian
This review article looks into possible mechanisms of neurocognitive effects of risperidone in patients with schizophrenia. Described are the results of clinical trials focusing on the impact of risperidone on neurocognitive deficit associated with dynamics of negative and positive symptoms of schizophrenia, comparative neurocognitive effects of risperidone and other antipsychotics of the first and second generation. The preliminary data are adduced confirming its favorable effect on neurocognitive indices of patients, commitment to low doses of risperidone in the maintenance phase of the pharmacotherapy of schizophrenia.
1. Завьялова Н.Е. Динамика психопатологических расстройств у пациентов с острой шизофренией при применении рисперидона и галоперидола // Соврем. терапия психических расстройств. - 2013. - № 4. - C. 19-24. 2. Мосолов С.Н., Кабанов С.О. Нейрокогнитивный дефицит у больных параноидной шизофренией в процессе терапии кветиапином, рисперидоном и галоперидолом // Психиатрия. - 2005. - № 1. - С. 38-49. 3. Desamericq G., Schurhoff F., Meary A. et al. Long-term neurocognitive effects of antipsychotics in schizophrenia: a network meta-analysis // Eur. J. Clin. Pharmacol. - 2014. - Vol. 70, N 2. - P. 127-134. 4. Dickinson D., Ramsey M.E., Gold J.M. Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia // Arch. Gen. Psychiatry. - 2007. - Vol. 64, N 5. - P. 532-542. 5. Elie D., Poirier M., Chianetta J. et al. Cognitive effects of antipsychotic dosage and polypharmacy: a study with the BACS in patients with schizophrenia and schizoaffective disorder // J. Psychopharmacol. - 2010. - Vol. 24. - P. 1037-1044. 6. Gallhofer B., Bauer U., Lis S. et al. Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs // Eur. Neuropsychopharmacol. - 1996. - Vol. 6, N 2. - P. 13-20. 7. Glahn D.C., Almasy L., Blangero J. et al. Adjudicating neurocognitive endophenotypes for schizophrenia // Am. J. Med. Genet. B. Neuropsychiatr. Genet. - 2007. - Vol. 144B, N 2. - P. 242-249. 8. Harvey P.D., Keefe R.S. Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment // Am. J. Psychiatry. - 2001. - Vol. 158. - P. 176-184. 9. Harvey P.D., Rabinowitz J., Eerdekens M., Davidson M. Treatment of cognitive impairment in early psychosis: a comparison of risperidone and haloperidol in a large long-term trial // Am. J. Psychiatry. - 2005. - Vol. 162, N 10. - P. 1888-1895. 10. Hecht E.M., Landy D.C. Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis // Schizophr. Res. - 2012. - Vol. 134. - P. 202-206. 11. Heinrichs R.W., Zakzanis K.K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence // Neuropsychology. - 1998. - Vol. 12, N 3. - P. 426-445. 12. Hill S.K., Schuepbach D., Herbener E.S. et al. Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia // Schizophr. Res. - 2004. - Vol. 68, N 1. - P. 49-63. 13. Hori H., Noguchi H., Hashimoto R. Antipsychotic medication and cognitive function in schizophrenia // Schizophr. Res. - 2006. - Vol. 86. - P. 138-146. 14. Hughes C., Kumari V., Soni W. et al. Longitudinal study of symptoms and cognitive function in chronic schizophrenia // Schizophr. Res. - 2003. - Vol. 59, N 2-3. - P. 137-146. 15. Keefe R.S., Silva S.G., Perkins D.O., Lieberman J.A. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis // Schizophr. Bull. - 1999. - Vol. 25. - P. 201-222. 16. Keefe R.S., Bilder R.M., Davis S.M. et al. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial // Arch. Gen. Psychiatry. - 2007. - Vol. 64, N 6. - P. 633-647. 17. Kim S.W., Chung Y.C., Lee Y.H. et al. Paliperidone ER versus risperidone for neurocognitive function in patients with schizophrenia: a randomized, open-label, controlled trial // Int. Clin. Psychopharmacol. - 2012. - Vol. 27, N 5. - P. 267-274. 18. Kucharska-Pietura K., Tylec A., Czernikiewicz A., Mortimer A. Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs // Med. Sci. Monit. - 2012. - Vol. 18, N 1. - P. 44-49. 19. Manschreck T.C., Boshes R.A. The CATIE schizophrenia trial: results, impact, controversy // Harv. Rev. Psychiatry. - 2007. - Vol. 15, N 5. - P. 245-258. 20. McGurk S.R., Green M.F., Wirshing W.C. et al. Antipsychotic and anticholinergic effects on two types of spatial memory in schizophrenia // Schizophr. Res. - 2004. - Vol. 68. - P. 225-233. 21. Meehl P.E. Schizotaxia revisited // Arch. Gen. Psychiatry. - 1989. - Vol. 46. - P. 935-944. 22. Remberk B., Namyslowska I., Rybakowski F. Cognition and communication dysfunctions in early-onset schizophrenia: effect of risperidone // Prog. Neuropsychopharmacol. Biol. Psychiatry. - 2012. - Vol. 39, N 2. - P. 348-354. 23. Rossi A., Mancini F., Stratta P. et al. Risperidone, negative symptoms and cognitive deficit in schizophrenia: an open study // Acta Psychiatr. Scand. - 1997. - Vol. 95, N 1. - P. 40-43. 24. Rybakowski J.K., Drozdz W., Borkowska. Long-term administration of the low-dose risperidone in schizotaxia subjects // Hum. Psychopharmacol. - 2007. - Vol. 22, N 6. - P. 407-412. 25. Sakurai H., Bies R.R., Stroup S.T. et al. Dopamine D2 Receptor Occupancy and Cognition in Schizophrenia: Analysis of the CATIE Data // Schizophr. Bull. - 2013. - Vol. 39, N 3. - P. 564-574. 26. Shaufer J., Giangrande E., Weinberger D.R., Dickinson D. The global cognitive impairment in schizophrenia: Consistent over decades and around the world // Schizophr. Res. - 2013. - Vol. 150, N 1. - P. 42-50. 27. Selva-Vera G., Balanza-Martinez V., Salazar-Fraile J. et al. The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia // BMC Psychiatry. - 2010. - Vol. 15, N 10. - P. 47. 28. Stip E., Lussier I. The effect of risperidone on cognition in patients with schizophrenia // Can. J. Psychiatry. - 1996. - Vol. 41, N 8. - P. 35-40. 29. Suzuki H., Gen K. The influence of switching from haloperidol decanoate depot to risperidone long-acting injection on the clinical symptoms and cognitive function in schizophrenia // Hum. Psychopharmacol. - 2012. - Vol. 27, N 5. - P. 470-475. 30. Suzuki H., Gen K., Inoue Y., Hibino H. et al. The influence of switching from risperidone to paliperidone on the extrapyramidal symptoms and cognitive function in elderly patients with schizophrenia: a preliminary open-label trial // Int. J. Psychiatry Clin. Pract. - 2014. - Vol. 18, N 1. - P. 58-62. 31. Takeuchi H., Suzuki T., Remington G. et al. Effects of Risperidone and Olanzapine Dose Reduction on Cognitive Function in Stable Patients With Schizophrenia: An Open-Label, Randomized, Controlled, Pilot Study // Schizophr. Bull. - 2013. - Vol. 39, N 5. - P. 993-998. 32. Thornton A.E., Van Snellenberg J.X., Sepehry A.A., Honer W. The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: a quantitative review // J. Psychopharmacol. (Oxford, England). - 2006. - Vol. 20, N 3. - P. 335-346. 33. Tuulio-Henriksson A., Arajarvi R., Partonen T. et al. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients // Biol. Psychiatry. - 2003. - Vol. 54, N 6. - P. 623-628. 34. Uchida H., Rajji T.K., Mulsant B.H. D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia // J. Clin. Psychopharmacol. - 2009. - Vol. 29. - P. 571-575. 35. Velligan D.I., Mahujin R.K., Diamond P.L. The functional significance of symptomatology and cognitive function in schizophrenia // Schizophr. Res. - 1997. - Vol. 25. - P. 21-31. 36. Ventura J., Thames A.D., Wood R.C. et al. Disorganization and reality distortion in schizophrenia: a meta-analysis of the relationship between positive symptoms and neurocognitive deficits // Schizophr. Res. - 2010. - Vol. 121, N 1-3. - P. 1-14. 37. Woodward N.D., Purdon S.E., Meltzer H.Y., Zald D.H. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia // Int. J. Neuropsychopharmacol. - 2005. - Vol. 8. - P. 457-472.
DOI: http://dx.doi.org/10.24411/1560-957X-2015-1%25x
Article Metrics
Metrics powered by PLOS ALM