Activity of glutathione metabolism enzymes in the blood cells in patients with late-onset schizophrenia
Suggested citation:
Tereshkina EB, Savushkina OK, Boksha IS, et al. [Activity of glutathione metabolism enzymes in the blood cells in patients with late-onset schizophrenia]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2020;(6):73-81. Russian
In the original study, 17 patients with late-onset schizophrenia (main group) and 19 women without mental and neurological diseases (comparison group) were examined in order to study the activity of glutathione reductase and glutathione S-transferase in platelets and erythrocytes. The activity of platelet glutathione-S-transferase in the main group correlated with the age of onset of the disease and is significantly and reliably reduced relative to the comparison group. In the subgroup of patients with a relatively earlier manifestation of the disease (up to 60 years), the activity of platelet glutathione reductase was significantly reduced. The results are important for assessing the degree of damage to the glutathione pathway of the antioxidant system in elderly patients.
Keywords glutathione reductase; glutathione S-transferase; erythrocytes; platelets; schizophrenia; late-onset schizophrenia
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DOI: http://dx.doi.org/10.24411/1560-957Х-2020-10609
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