Cognitive features of patients with bipolar disorder in comorbidity with alcohol use disorders
Suggested citation:
Galkin SA, Bokhan NA. [Cognitive features of patients with bipolar disorder in comorbidity with alcohol use disorders]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2022;(3):57-61. Russian
In an empirical study to identify the features of cognitive functioning of patients with bipolar disorder in comorbidity with alcohol use disorders, 74 patients with bipolar disorder were examined, of which 28 had the presence of comorbid alcohol use disorders. Go/No-go, Corsi and Color Stroop tests were used to assess cognitive functions. It was found that in the presence of comorbid alcohol use disorders, patients with bipolar disorder have more pronounced cognitive impairments in the form of a decrease in psychomotor reaction and cognitive flexibility.
Keywords bipolar disorder; alcohol use disorders; comorbidity; cognitive functions; psychomotor reaction; cognitive flexibility
1. Vasilyeva SN, Simutkin GG, Schastny ED. [Clinical and dynamic characteristics of bipolar affective disorder in comorbidity with other mental disorders]. Sibirskij vestnik psihiatrii i narkologii. 2017;(2):16–20. (In Russ.) 2. Bokhan NA, Semke VYa. Komorbidnost' v narkologii. Tomsk, 2009. 498 p. (In Russ.) 3. Grunze H, Schaefer M, Scherk H, et al. Comorbid Bipolar and Alcohol Use Disorder – A Therapeutic Challenge. Front Psychiatry. 2021;(12):660432. DOI: https://doi.org/10.3389/fpsyt.2021.660432 4. Simhandl C, Radua J, König B, et al. Prevalence and impact of comorbid alcohol use disorder in bipolar disorder: A prospective follow-up study. Aust N Z J Psychiatry. 2016;50(4):345–51. DOI: https://doi.org/10.1177/0004867415585855 5. Galkin SA, Roshchina OV, Kisel NI, et al. Clinical and neurophysiological characteristics of alcohol dependence and its comorbidity with affective disorders. Neurosci Behav Physiol. 2021;51(6):720–3. DOI: https://doi.org/10.1007/s11055-021-01127-w 6. Levy B, Monzani BA, Stephansky MR, et al. Neurocognitive impairment in patients with co-occurring bipolar disorder and alcohol dependence upon discharge from inpatient care. Psychiatry Res. 2008;161(1):28–35. DOI: https://doi.org/10.1016/j.psychres.2007.09.009 7. Levy B, Manove E, Weiss RD. Recovery of cognitive functioning in patients with co-occurring bipolar disorder and alcohol dependence during early remission from an acute mood episode. Ann Clin Psychiatry. 2012;24(2):143–54. PMID: 22563570 8. Sanchez-Moreno J, Martinez-Aran A, Colom F, et al. Neurocognitive dysfunctions in euthymic bipolar patients with and without prior history of alcohol use. J Clin Psychiatry. 2009;70(8):1120–7. DOI: https://doi.org/10.4088/JCP.08m04302 9. Mur M, Portella MJ, Martínez-Aran A, et al. Persistent neuropsychological deficit in euthymic bipolar patients: executive function as a core deficit. J Clin Psychiatry. 2007;68(7):1078–86. DOI: https://doi.org/10.4088/jcp.v68n0715 10. van Gorp WG, Altshuler L, Theberge DC, et al. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Arch Gen Psychiatry. 1998;55(1):41–6. DOI: https://doi.org/10.1001/archpsyc.55.1.41 11. van der Werf-Eldering MJ, Burger H, Holthausen EA, et al. Cognitive functioning in patients with bipolar disorder: association with depressive symptoms and alcohol use. PLoS One. 2010;5(9):e13032. DOI: https://doi.org/10.1371/journal.pone.0013032 12. Gomez P, Ratcliff R, Perea M. A model of the go/no-go task. J Exp Psychol Gen. 2007;136(3):389–413. DOI: https://doi.org/10.1037/0096-3445.136.3.389 13. Corsi P.M. Human memory and the medial temporal region of the brain [dissertation]. Montreal: University Montreal; 1972. 78 p. 14. Galkin SA, Peshkovskaya AG, Simutkin GG, et al. Impairments to the functions of spatial working memory in mild depression and their neurophysiological correlates. Neurosci Behav Physiol. 2020;50(7):825–9. DOI: https://doi.org/10.1007/s11055-020-00973-4 15. Scarpina F, Tagini S. The Stroop Color and Word Test. Front Psychol. 2017;8:557. DOI: https://doi.org/10.3389/fpsyg.2017.00557 16. Galkin SA, Peshkovskaya AG, Roshchina OV, et al. [Features of brain activity in alcohol dependence in the task of inhibitory control]. Byulleten' sibirskoj mediciny. 2020;19(4):38–45. (In Russ.) DOI: https://doi.org/10.20538/1682-0363-2020-4-38-45 17. Korepanov AL, Ivanova YaA. [Investigation of psychomotor reactions in adolescents with different levels of physical development]. Avtonomiya lichnosti. 2010;1(1):129–37. (In Russ.) 18. Hoffman LA, Sklar AL, Nixon SJ. The effects of acute alcohol on psychomotor, set-shifting, and working memory performance in older men and women. Alcohol. 2015;49(3):185–91. DOI: https://doi.org/10.1016/j.alcohol.2015.02.001 19. Dajani DR, Uddin LQ. Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience. Trends Neurosci. 2015;38(9):571–8. DOI: https://doi.org/10.1016/j.tins.2015.07.003 20. Kim C, Johnson NF, Cilles SE, et al. Common and distinct mechanisms of cognitive flexibility in prefrontal cortex. J Neurosci. 2011;31(13):4771–9. DOI: https://doi.org/10.1523/JNEUROSCI.5923-10.2011
DOI: http://dx.doi.org/10.47877/1560-957Х-2022-10307
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