Neurocognitive correlates of bipolar affective disorder
Suggested citation:
Shipkova KM, Dovzhenko TV. [Neurocognitive correlates of bipolar affective disorder]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2022;(5):30-38. Russian
This review analyzes the neurocognitive correlates of bipolar affective disorder, the specifics of the neurocognitive profile of the disease and prognostic criteria for assessing its rehabilitative neurocognitive potential. It is shown that the following basic components of behavior regulation and their derivatives are disturbed during bipolar affective disorder: construction of conclusions, planning activities, solving complex behavioral and mental tasks. Bipolar affective disorder affects productivity of the processes of “cold” and “hot” cognition, inhibitory processes, working memory, attention, and forms cognitive rigidity. Neurocognitive deficit is persistent and does not regress in the euthymic period. Bipolar affective disorder leads to morphological changes in the dorsolateral, orbitofrontal, ventromedial prefrontal cortex, anterior cingulate gyrus and amygdala; there is a decrease in the thickness of gray matter.
Keywords bipolar affective disorder; neurocognitive correlates; neuropsychological assessment; neurocognitive deficits; endophenotype
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DOI: http://dx.doi.org/10.47877/1560-957Х-2022-10503
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