Роль нарушения целостности гематоэнцефалического барьера в развитии двигательных нарушений при аутоиммунных заболеваниях, сопровождающихся психопатологической симптоматикой
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Барканова В., Шмуклер А.Б. Роль нарушения целостности гематоэнцефалического барьера в развитии двигательных нарушений при аутоиммунных заболеваниях, сопровождающихся психопатологической симптоматикой // Российский психиатрический журнал. 2023. №3. С. 91-103.
В данном систематическом обзоре осуществлен анализ роли целостности гематоэнцефалического барьера в отношении развития двигательных нарушений у пациентов с аутоиммунными заболеваниями, проявляющимися широким спектром психических расстройств: от легких аффективных нарушений до психотической симптоматики с кататоническими включениями. Обзор выполнен по критериям PRISMA 2020 и включает в себя 19 исследований. Показано, что повреждения гематоэнцефалического барьера и высокого титра антител не всегда достаточно для возникновения развернутой клинической картины заболевания. Развитие кататонической симптоматики не во всех случаях сопровождается одновременным повреждением гематоэнцефалического барьера. Однако для тяжелого течения заболевания характерно такое повреждение. Подчеркивается важность других, сопутствующих факторов в развитии двигательных нарушений при аутоиммунных заболеваниях, клиническая картина которых включает психопатологическую симптоматику.
Ключевые слова психопатологическая симптоматика; кататония; двигательные нарушения; гематоэнцефалический барьер; аутоиммунные заболевания; анти-NMDA-рецепторный энцефалит; нейропсихиатрическая системная красная волчанка; антифосфолипидный синдром
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