Прогнозирование психических расстройств у несовершеннолетних с помощью нейросетевого анализа данных
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Бодагова Е.А., Говорин Н.В., Мудров В.А. Прогнозирование психических расстройств у несовершеннолетних с помощью нейросетевого анализа данных // Российский психиатрический журнал. 2023. №5. С. 45-54.
В оригинальном исследовании с целью оценки возможности прогнозирования психических расстройств у несовершеннолетних с помощью нейросетевого анализа данных было проведено клиническое обследование 516 детей, оставшихся без попечения родителей, и 100 детей и подростков, проживающих в своих биологических полных семьях. Было выполнено молекулярно-генетическое типирование, определены частоты генотипов и аллелей полиморфных вариантов генов: rs1800532 TPH1(A218C), rs6323 MAOA (R297R), rs6313 HTR2A (T102C), rs1800955 DRD4 (C-521T), rs4680 COMT (G472A), rs1611115 DBH (C-1021T), rs1800497 DRD2 (Taq1A). Результаты исследования показали, что дети-сироты отличаются от детей из полных семей по следующим параметрам: отягощенная алкоголизмом наследственность (p<0,001), патология перинатального периода (p<0,001), частая встречаемость полиморфизмов генов rs1800532 TPH1(A218C) (p=0,012) и rs4680 COMT (G472A) (p=0,009). Статистически значимые параметры легли в основу обучения многослойного перцептрона. Применение нейросетевого анализа позволило прогнозировать развитие психических расстройств с точностью не менее 83,0%.
Ключевые слова дети, оставшиеся без попечения родителей; социальные сироты; психические нарушения; полиморфизм генов; нейросетевой анализ; многослойный перцептрон
1. Devjatova OE. Pogranichnye psihicheskie rasstrojstva u detej, nahodjashhihsja v uslovijah semejnoj deprivacii [PhD thesis]. [Moscow (Russia)]: Gosudarstvennyj nauchnyj centr social'noj i sudebnoj psihiatrii [State Research Center for Social and Forensic Psychiatry]; 2005. 20 p. (In Russ.) 2. Kremneva LF, Proselkova MO, Kozlovskaja GV. [On the question of the etiology of the orphan syndrome]. Social'naja i klinicheskaja psihiatrija [Social and clinical psychiatry]. 2017;(1):20–5. (In Russ.) 3. Akhmetova VV, Tarasova TP, Govorin NV. Emotsional'nye i volevye narusheniya v usloviyakh materinskoy deprivatsii: monografiya. Kazan: Buk; 2020. 162 p. (In Russ.) 4. Vetoshkina SA. [Features of the emotional sphere in orphans]. Sovremennaya zarubezhnaya psikhologiya [Modern foreign psychology]. 2015;(1):15–25. (In Russ.) 5. Bobrov AE. [The dependence of deviant forms of behavior in pupils of social protection institutions on the nature of their traumatic experience]. Vestnik psikhoterapii [Bulletin of Psychotherapy]. 2018;68(73):68–82. (In Russ.) 6. Egorova PL. [Risk factors for mental disorders in orphans in adolescence]. Vestnik Ivanovskoy meditsinskoy akademii [Bulletin of the Ivanovo Medical Academy]. 2015;2(2):57–61. (In Russ.) 7. Kryuchkova AS, Ermakov PN, Abakumova IV. [Analysis of associations of polymorphism of the MAOA gene with aggressive and hostile strategies in behavior in adolescents and young people]. Rossijskij psikhologicheskij zhurnal [Russian Psychological Journal]. 2016;13(1):115–24. (In Russ.) 8. Nilsson KW, Аslund C, Comasco E, et al. Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions. J Neural Transm. 2018;125(11):1601–26. DOI: https://doi.org/10.1007/s00702-018-1892-2 9. Alfimova MV. [Personality traits, control functions and genetic features of monoamine metabolism]. Psikhologiya. ZHurnal Vysshej shkoly ehkonomiki [Psychology. Journal of the Higher School of Economics]. 2009;6(4):24–41. (In Russ.) 10. Barskii VI. Analiz svyazi polimorfizma genov dofaminovoj i serotoninovoj sistem s lichnostnymi kharakteristikami podrostkov v psikhogigienicheskikh issledovaniyakh [PhD thesis]. [Moscow (Russia]: Nauchno-issledovatel'skij institut jekologii cheloveka i gigieny okruzhajushhej sredy im A.N. Sysina [Scientific Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysin]; 2011. 29 p. (In Russ.) 11. Sukhodol'skaya EM. Izuchenie allel'nogo polimorfizma genov nejromediatornykh sistem, assotsiirovannykh s povedencheskimi reaktsiyami [PhD thesis]. [Moscow (Russia)]: Institut biologii gena Rossijskoj akademii nauk [Institute of Gene Biology of the Russian Academy of Sciences]; 2016. 25 р. (In Russ.) 12. Levchuk LA, Shmigol' MV, Ivanova SA. [The serotonergic system in the pathogenesis and therapy of depressive disorders]. Sibirskij vestnik psikhiatrii i narkologii [Siberian Bulletin of Psychiatry and Narcology]. 2012;2(71):75–9. (In Russ.) 13. Mudrov VA. Algoritmy statisticheskogo analiza dannykh biomeditsinskikh issledovanij s pomoshh'yu paketa programm SPSS (dostupnym yazykom). Moscow: Logosfera; 2022. 143 р. (In Russ.) URL: https://www.books-up.ru/en/excerpt/algoritmy-statisticheskogo-analiza-dannyh-biomedicinskih-issledovanij-s-pomocshyu-paketa-programm-spss-dostupnym-yazykom-15704570/?page=1 (accessed on: 17.05.2023). 14. Byrd A, Manuck S, Hawes S, et al. The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism. Dev Psychopathol. 2019;31(1):361–77. DOI: https://doi.org/10.1017/S0954579417001900 15. Auerbach JG, Faroy M, Ebstein R, et al. The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry. 2001;42(6):777–83. DOI: https://doi.org/10.1111/1469-7610.00774 16. Kibitov AO, Voskoboeva EYu, Chuprova NA. [Polymorphic variants of 444 G/A and -1021 C/T of the dopamine-β-hydroxylase (DBH) gene change the trajectory of alcohol dependence]. Zh Nevrol Psikhiatr Im SS Korsakova. 2015;115(5):68–75. (In Russ.) 17. Moffitt TE, Caspi A. Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression. BMC Psychiatry. 2014;14:179. DOI: https://doi.org/10.1186/1471-244X-14-179 18. Sidorova EU, Akhmetova EA, Ashurov ZS, et al. [Genetic associations of polymorphic variants of MTNR1A (rs34532313), MTNR1B (rs10830963), CLOCK (rs1801260), DRD2 (rs1800497) genes with forms of suicidal behavior in patients with alcohol dependence]. Akademicheskij zhurnal Zapadnoj Sibiri [Academic Journal of Western Siberia]. 2022;18(1):23–9. (In Russ.) DOI: https://doi.org/10.32878/sibir.22-18-01(94)-23-29 19. Davydova YuD, Gumerova OV. [The use of molecular and bioinformatic approaches to study the effect of the serotonin system on the level of anxiety in students]. Vestnik Bashkirskogo gosudarstvennogo pedagogicheskogo universiteta im. M. Akmully [Bulletin of the Bashkir State Pedagogical University named after M. Akmulla]. 2016;3(39):146–52. (In Russ.) 20. Moskaleva PV, Shnaider NA, Dmitrenko DV, et al. [Association of polymorphism of TPH1 and TPH2 genes with the risk of neuropsychiatric disorders]. Uspekhi fiziologicheskikh nauk [Successes of physiological sciences]. 2021;52(2):51–60. (In Russ.) 21. Ono H, Shirakawa O, Kitamura N, et al. Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls. Mol Psychiatry. 2002;7:1127–32. DOI: https://doi.org/10.1038/sj.mp.4001150 22. Kovsh EM, Ermakov PN, Vorob'eva EV. [Association of the polymorphic marker VAL158MET of the COMT gene with the level of aggressiveness and strategies of behavior in conflict in girls aged 18–24]. Severokavkazskij psikhologicheskij vestnik [North Caucasian Psychological Bulletin]. 2015;13(3):15–21. (In Russ.) 23. Vetulani J. Neurochemistry of impulsiveness and aggression. Psychiatr Pol. 2013;47(1):103–15. PMID: 23888748 24. Soyka M. Val158Met COMT polymorphism and risk of aggression in alcohol dependence. Addict Biol. 2015;20(1):197–204. DOI: https://doi.org/10.1111/adb.12098
DOI: http://dx.doi.org/10.34757/1560-957X.2023.27.5.006
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