Ассоциация неблагоприятного детского опыта с показателями суицидальности при биполярном расстройстве, рекуррентном депрессивном расстройстве и шизофрении: сравнительный анализ
|
Полный текст:
Только для подписчиков
|
Рекомендуемое оформление библиографической ссылки:
Жиляева Т.В., Горбунова А.П., Мазо Г.Э. Ассоциация неблагоприятного детского опыта с показателями суицидальности при биполярном расстройстве, рекуррентном депрессивном расстройстве и шизофрении: сравнительный анализ // Российский психиатрический журнал. 2025. №5. С. 12-25.
В кросс-секционном мультицентровом исследовании с целью сравнения особенностей ассоциации неблагоприятного детского опыта (НДО) с показателями суицидальности у пациентов с биполярным аффективным расстройством (БАР), рекуррентным депрессивным расстройством (РДР) и шизофренией были обследованы 281 пациент с установленными диагнозами БАР (F31, n=134), РДР (F33, n=45) и шизофрении (F20, n=102) вне зависимости от стадии (обострения или ремиссии). Оценивались 8 показателей суицидальности с помощью Колумбийской шкалы оценки тяжести суицида (C-SSRS) и особенности НДО с помощью Международного опросника НДО (Adverse Childhood Experience – International Questionnaire, ACE-IQ). Обнаружено, что показатели НДО имеют множественные ассоциации с показателями суицидальности при БАР, РДР и шизофрении, однако при каждом психическом расстройстве профиль этих взаимосвязей отличается от такового при других изученных расстройствах, что может свидетельствовать о разной патогенетической роли отдельных вариантов НДО, а также о разных особенностях семейного окружения у лиц, страдающих разными психическими расстройствами.
Ключевые слова суицид; неблагоприятный детский опыт; биполярное аффективное расстройство; рекуррентное депрессивное расстройство; шизофрения
1. Lacey RE, Minnis H. Practitioner Review: Twenty years of research with adverse childhood experience scores – Advantages, disadvantages and applications to practice. J Child Psychol Psychiatry. 2020;61(2):116–30. doi: 10.1111/jcpp.13135 2. Matheson SL, Shepherd AM, Pinchbeck RM, et al. Childhood adversity in schizophrenia: a systematic meta-analysis. Psychol Med. 2013;43(2):225–38. doi: 10.1017/S0033291712000785 3. Hughes K, Bellis MA, Hardcastle KA, et al. The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Health. 2017;2(8):e356–66. doi: 10.1016/S2468-2667(17)30118-4 4. Herzog JI, Schmahl C. Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan. Front Psychiatry. 2018;9:420. doi: 10.3389/fpsyt.2018.00420 5. Westermair AL, Stoll AM, Greggersen W, et al. All Unhappy Childhoods Are Unhappy in Their Own Way-Differential Impact of Dimensions of Adverse Childhood Experiences on Adult Mental Health and Health Behavior. Front Psychiatry. 2018;9:198. doi: 10.3389/fpsyt.2018.00198 6. LaNoue MD, George BJ, Helitzer DL, Keith SW. Contrasting cumulative risk and multiple individual risk models of the relationship between Adverse Childhood Experiences (ACEs) and adult health outcomes. BMC Med Res Methodol. 2020;20(1):239. doi: 10.1186/s12874-020-01120-w 7. Dunn EC, McLaughlin KA, Slopen N, et al. Developmental timing of child maltreatment and symptoms of depression and suicidal ideation in young adulthood: results from the National Longitudinal Study of Adolescent Health. Depress Anxiety. 2013;30(10):955–64. doi: 10.1002/da.22102 8. Gibb BE, Alloy LB, Abramson LY, et al. Childhood maltreatment and college students' current suicidal ideation: a test of the hopelessness theory. Suicide Life Threat Behav. 2001;31(4):405–15. doi: 10.1521/suli.31.4.405.22042 9. Hardt J, Herke M, Schier K. Suicidal ideation, parent-child relationships, and adverse childhood experiences: a cross-validation study using a Graphical Markov Model. Child Psychiatry Hum Dev. 2011;42(2):119–33. doi: 10.1007/s10578-010-0203-4 10. Brezo J, Paris J, Vitaro F, et al. Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry. 2008;193(2):134–9. doi: 10.1192/bjp.bp.107.037994 11. Розанов В.А. Гены и суицидальное поведение. Суицидология. 2013:4(10):3–14. 12. Turecki G, Ernst C, Jollant F, et al. The neurobehavioral origins of suicidal behavior. Trends in Neurosciences. 2012;35:14–23. 13. Ludwig B, Roy B, Wang Q, et al. The Life Span Model of Suicide and Its Neurobiological Foundation. Front. Neurosci. 2017;11:74. 14. Berardelli I, Sarubbi S, Rogante E, et al. Association between Childhood Maltreatment and Suicidal Ideation: A Path Analysis Study. J Clin Med. 2022. 13;11(8):2179. doi: 10.3390/jcm11082179 15. Schlensog-Schuster F, Keil J, Von Klitzing K, et al. From Maltreatment to Psychiatric Disorders in Childhood and Adolescence: The Relevance of Emotional Maltreatment. Child maltreatment. 2024.29(1):142–54. doi: 10.1177/10775595221134248 16. Sekowski M, Gambin M, Cudo A, et al. The relations between childhood maltreatment, shame, guilt, depression and suicidal ideation in inpatient adolescents. J affect disord. 2020;276:667–77. doi: 10.1016/j.jad.2020.07.056 17. Agnew-Blais J, Danese A. Childhood Maltreatment and Unfavourable Clinical Outcomes in Bipolar Disorder: A Systematic Review and Meta-Analysis. Lancet Psychiatry. 2016;3:342–9. doi: 10.1016/S2215-0366(15)00544-1 18. Etain B, Aas M, Andreassen OA, et al. Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry. 2013;74(10):991–8. doi: 10.4088/JCP.13m08353 19. Garno JL, Goldberg JF, Ramirez PM, Ritzler BA. Impact of childhood abuse on the clinical course of bipolar disorder. British Journal of Psychiatry. 2005;186(2):121–5. doi: 10.1192/bjp.186.2.121 20. Janiri D, Sani G, Danese E, et al. Childhood traumatic experiences of patients with bipolar disorder type I and type II. J Affect Disord. 2015;175:92–7. doi: 10.1016/j.jad.2014.12.055 21. Hansson C, Joas E, Pålsson E, Hawton K, Runeson B, Landén M. Risk factors for suicide in bipolar disorder: a cohort study of 12 850 patients. Acta Psychiatr Scand. 2018;138(5):456–63. doi: 10.1111/acps.12946 22. Hassan AN, Stuart EA, De Luca V. Childhood maltreatment increases the risk of suicide attempt in schizophrenia. Schizophr Res. 2016;176(2-3):572–7. doi: 10.1016/j.schres.2016.05.012 23. Zhang Y, Fang X, Tang B, et al. Childhood Trauma and Insomnia Increase Suicidal Ideation in Schizophrenia Patients: A Cross-Sectional Study. Front Psychiatry. 2021;12:769743. doi: 10.3389/fpsyt.2021.769743 24. Cheng P, Ju P, Xia Q, et al. Childhood maltreatment increases the suicidal risk in Chinese schizophrenia patients. Front Psychiatry. 2022;13:927540. doi: 10.3389/fpsyt.2022.927540 25. Hosang GM, Fisher HL, Hodgson K, et al. Childhood maltreatment and adult medical morbidity in mood disorders: comparison of unipolar depression with bipolar disorder. The British journal of psychiatry: the journal of mental science. 2018;213(5):645–53. doi: 10.1192/bjp.2018.178 26. Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD10. J. Clin. Psychiatry. 1998;59(20):22–33. 27. Posner K, Oquendo MA, Gould M, et al. Columbia Classification Algorithm of Suicide Assessment (C-CASA): Classification of Suicidal Events in the FDA’s Pediatric Suicidal Risk Analysis of Antidepressants. Am J Psychiatry. 2007;164:1035–43. 28. Oquendo MA, Halberstam B, Mann JJ, Risk factors for suicidal behavior: utility and limitations of research instruments. In: First M.B (Ed.). Standardized Assessment for the Clinician. APPI, Washington, D.C; 2003. Р. 537539. 29. Tsukarzi EE. Suitsid: otsenka riskov i pervaya pomoshch'. Opredelenie urovnya suitsidal'nogo riska c pomoshch'yu Kolumbiiskoi Shkaly Otsenki Tyazhesti Suitsida (C-SSRS). Sovremennaya Terapiya Psikhicheskikh Rasstroistv. 2011;(2): 30–40. (In Russ.) 30. WHO Violence Prevention Team. Adverse Childhood Experiences International Questionnaire (ACE-IQ). 2020. URL: https://www. who.int/publications/m/item/adverse-childhood-experiences-international-questionnaire-(ace-iq) (accessed on: 20.04.2023). 31. Kibitov AA., Trusova AV, Vyshinskii KV, et al. Razrabotka i analiz psikhometricheskikh svoistv novoi russkoyazychnoi versii Mezhdunarodnogo oprosnika neblagopriyatnogo detskogo opyta (ACE-IQ). Konsul'tativnaya psikhologiya i psikhoterapiya. 2024;32(1):29–57. (In Russ.) doi: 10.17759/cpp.2024320102 32. Angst J, Adolfsson R, Benazzi F, et al. The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. J Affect Disord. 2005;88(2):217–33. doi: 10.1016/j.jad.2005.05.011 33. Mosolov SN, Ushkalova AV, Kostyukova EG, et al. [Validation of the HCL-32 Russian version for detection of Bipolar II Disorder patients among those with diagnosis of recurrent depressive disorder]. Sotsial'naya i klinicheskaya psikhiatriya [Social and Clinical Psychiatry]. 2015;25(1):21–30. (In Russ.) 34. Köhler-Forsberg O, Ge F, Hauksdóttir A, et al. Adverse childhood experiences and psychological functioning among women with schizophrenia or bipolar disorder: population-based study. The British journal of psychiatry: the journal of mental science. 2024;224(1):6–12. doi: 10.1192/bjp.2023.128 35. Brancati GE, Nunes A, Scott K, et al. Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment. International journal of bipolar disorders. 202311(1):25. doi: 10.1186/s40345-023-00304-9 36. Dempsey RC, Dodd AL, Gooding PA, Jones SH. The Types of Psychosocial Factors Associated with Suicidality Outcomes for People Living with Bipolar Disorder: A Scoping Review. International journal of environmental research and public health. 2024;21(5):525. doi: 10.3390/ijerph21050525 37. Brandt JM, Gregersen M, Søndergaard A, et al. Associations between exposure to early childhood adversities and middle childhood psychotic experiences in children at familial high risk of schizophrenia, bipolar disorder, and population-based controls: The Danish high risk and resilience study – VIA 7 and VIA 11. Psychological medicine. 2023;53(14):6635–45. doi: 10.1017/S0033291722004020 38. Brandt JM, Hemager N, Gregersen M, et al. Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. The Danish High Risk and Resilience Study – VIA 7 and VIA 11. The British journal of clinical psychology. 2022;61(4):875–94. doi: 10.1111/bjc.12364 39. Zhu J, Lowen SB, Anderson CM, et al. Association of Prepubertal and Postpubertal Exposure to Childhood Maltreatment With Adult Amygdala Function. JAMA psychiatry. 2019;76(8):843–53. doi: 10.1001/jamapsychiatry.2019.0931 40. Malter Cohen M, Jing D, Yang RR, et al. Early-life stress has persistent effects on amygdala function and development in mice and humans. Proc Nat Acad Sci USA. 2013;110:18274–8. doi: 10.1073/pnas.1310163110 41. Garrett AS, Miklowitz DJ, Howe ME, et al. Changes in brain activation following psychotherapy for youth with mood dysregulation at familial risk for bipolar disorder. Progress Neuro-Psychopharmacol Biol Psychiatry. 2015;56:215–20. doi: 10.1016/j.pnpbp.2014.09.007 42. Zaehringer J, Ende G, Santangelo P, et al. Improved emotion regulation after neurofeedback: A single-arm trial in patients with Borderline Personality Disorder. NeuroImage: Clin. 2019;24:102032. doi: 10.1016/j.nicl.2019.102032 43. Aas M, Aminoff SR, Vik Lagerberg T, et al. Affective lability in patients with bipolar disorders is associated with high levels of childhood trauma. Psychiatry Res. 2014;218(1-2):252–5. doi: 10.1016/j.psychres.2014.03.046 44. Neacsiu AD, Fang CM, Rodriguez M, Rosenthal MZ. Suicidal Behavior and Problems with Emotion Regulation. Suicide Life Threat Behav. 2018;48(1):52–74. doi: 10.1111/sltb.12335 45. Hu FH, Jia YJ, Zhao DY, et al. Gender differences in suicide among patients with bipolar disorder: A systematic review and meta-analysis. Journal of affective disorders. 2023;339:601–14. doi: 10.1016/j.jad.2023.07.060 46. Miller JN, Black DW. Bipolar Disorder and Suicide: a Review. Current psychiatry reports. 2020;22(2):6. doi: 10.1007/s11920-020-1130-0
Метрики статей
Metrics powered by PLOS ALM