Генетические аспекты агрессивного поведения у больных шизофренией (аналитический обзор)

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Мустафина Т., Леопольд А.В., Павлов К.А., Кекелидзе З.И., Макушкин Е.В., Фастовцов Г.А., Чехонин В.П. Генетические аспекты агрессивного поведения у больных шизофренией (аналитический обзор) // Российский психиатрический журнал. 2014. №3. С. 67-78.

Аннотация

В статье представлен обзор литературы по вопросу доказательных исследований в психиатрии и практической ценности получаемых в них результатов. Осуществленный анализ позволяет сделать вывод о том, что современные методы молекулярной биологии предоставляют новые инструменты описания и анализа ассоциации ряда однонуклеотидных полиморфизмов с агрессивным поведением у больных шизофренией, что может использоваться при разработке комплексных критериев определения генетического риска у носителей предрасполагающего генотипа полиморфных маркеров для выбора оптимальной психокоррекционной стратегии.

Литература

1. Алфимова М.В., Трубников В.И. Генные основы темперамента и личности // Вопр. психол. – 2000. – № 3. – С. 128–139. 2. Алфимова М. В., Трубников В.И. Психогенетика агрессивности // Вопр. психол. –2000. – № 6. – С. 42–54. 3. Голимбет В.Е., Коровайцева Г.И., Брусов О.С. Функциональное состояние серотонинергической системы и полиморфизм 5HTTLPR гена переносчика серотонина у больных шизофренией // Молекул. биол. – 2010. – Т. 44, № 2. – С. 251–256. 4. Дмитриева Т.Б. Агрессия и психическое здоровье / Под ред. Т.Б. Дмитриевой, Б.В. Шостаковича. – СПб: Юридический центр Пресс, 2002. – С. 3–9. 5. Дмитриева Т.Б., Положий Б.С. Психическое здоровье россиян // Человек. – 2002. – № 6. – С. 21–31. 6. Кондратьев Ф.В. Криминальная агрессия – актуальная проблема судебной психиатрии // Рос. психиатр. журн. – 2006. – № 1. – С. 17–20. 7. Михайлова Т.И. Психогенетические предпосылки агрессивности // Вісник Сумського державного університету. Серія Медицина. – 2012. – № 1. – С. 155–163. 8. Мохонько А.Р., Муганцева Л.А. Основные показатели деятельности судебно-психиатрической службы Российской Федерации в 2011 году: Аналитический обзор. – М.: ГНЦССП им. В.П. Сербского, 2012. – Вып. 20. – 196 с. 9. Соловьева С.Л. Агрессивность как свойство личности в норме и патологии: Автореф. дис. … д-ра психол. наук. – СПб., 1996. 10. Стояк В.А., Иванова С.А. Нейромедиаторные системы в регуляции агрессивного поведения (обзор литературы) // Сибир. вестн. психиатрии и наркологии. – 2010. – № 3. – С. 70–76. 11. Шостакович Б.В., Горинов В.В. Агрессия, агрессивное поведение и психопатология: постановка проблемы // Агрессия и психическое здоровье / Под ред. Т.Б. Дмитриевой, Б.В. Шостаковича. – СПб.: Юридический центр Пресс, 2002. – С. 10–22. 12. Aluja A., Garcia L.F., Blanch A., Fibla J. Association of androgen receptor gene, CAG and GGN repeat length polymorphism and impulsive-disinhibited personality traits in inmates: the role of short-long haplotype // Psychiatr. Genet. – 2011. – Vol. 21. – P. 229–239. 13. Anastasi A., Foley J.P. A proposed reorientation in the heredityenvironment controversy // Psychol. Rev. – 1948. – Vol. 55. – P. 239–249. 14. Baker K.G., Halliday G.M., Halasz P. et al. Cytoarchitecture of serotonin-synthesizing neurons in the pontine tegmentum of the human brain // Synapse – 1991. – Vol. 7, N 4. – P. 301–320. 15. Beitchman J.H., Baldassarra L., Mik H. et al. Serotonin transporter polymorphisms and persistent, pervasive childhood aggression // Am. J. Psychiatry. – 2006. – Vol. 163, N 6. – P. 1103–1105. 16. Bengel D., Heils A., Petri S. et al. Gene structure and 5’-flanking regulatory region of the murine serotonin transporter // J. Brain Res. Mol. Brain Res. – 1997. – Vol. 44, N 2. – P. 286–292. 17. Benko A., Lazary J., Molnar E. et al. Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity // J. Med. Genet. B. Neuropsychiatr. Genet. – 2010. – Vol. 53B, N 2. – P. 592–599. 18. Benmessaoud D., Hamdani N., Boni C. et al. Excess of transmission of the G allele of the -1438A/G polymorphism of the 5-HT2A receptor gene in patients with schizophrenia responsive to antipsychotics // BMC Psychiatry. – 2008. – Vol. 30, N 8. – P. 40. 19. Boke O., Gunes S., Kara N. et al. Association of serotonin 2A receptor and lack of association of CYP1A2 gene polymorphism with tardive dyskinesia in a Turkish population // DNA Cell. Biol. – 2007. – Vol. 26, N 8. – P. 527–531. 20. Bortolato M., Godar S.C., Melis M. et al. NMDARs mediate the role of monoamine oxidase A in pathological aggression // J. Neurosci. – 2012. – Vol. 32, N 25. – P. 8574–8582. 21. Brunner H.G., Nelen M., Breakefield X.O. et al. Abnormal behavior associated with a point mutation in the structural gene for monoamineoxidase A // Science. – 1993. – Vol. 262 (5133). – P. 578–580. 22. Burks B.S. The relative influence of nature and nurture upon mental development; a comparative study of fosterparent-foster-child resemblance and true-parent-true-child resemblance // 27th Yearbook of the National Society for the Study of Education. – Bloomington, Ill: Public School Publishing Co, 1928. – Pt I. – P. 219–316. 23. Cadoret R.J., Langbehn D., Caspers K. et al. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population // Compr. Psychiatry. – 2003. – Vol. 44, N 2. – P. 88–101. 24. Carlstrцm E.L., Saetre P., Rosengren A. et al. Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia // J. Behav. Brain Functions. – 2012. – Vol. 8. – P. 24. 25. Caspi A., McClay J., Moffitt T.E. et al. Role of genotype in the cycle of violence in maltreated children // Science. – 2002. – Vol. 297. – P. 851–854. 26. Chistiakov D.A., Kekelidze Z.I., Chekhonin V.P. Endophenotypes as a measure of suicidality // J. Appl. Genet. – 2012. – Vol. 53, N 4. – P. 389–413. 27. Coccaro E.F., Bergeman C.S., Kavoussi R.J., Seroczynski A.D. Heritability of aggression and irritability: a twin study of the Buss-Durkee aggression scales in adult male subjects // Biol. Psychiatry. – 1997. – Vol. 41. – P. 273–284. 28. Coccaro E.F., Siever L.J. The neuropsychopharmacology of personality disorders // Psychopharmacology: The Fourth Generation of Progress / Eds F.E. Bloom, D.J. Kupfer. – N.Y.: Raven Press, 1995. – P. 1567–1579. 29. Craig I.W. The importance of stress and genetic variation in human aggression // Bioessays. – 2007. – Vol. 29, N 3. – P. 227–236. 30. Davidge K.M., Atkinson L., Douglas L. et al. Association of the serotonin transporter and 5HT1Dbeta receptor genes with extreme, persistent and pervasive aggressive behaviour in children // J. Psychiatr. Genet. – 2004. – Vol. 14, N 3. – P. 143–146. 31. Deckert J., Catalano M., Syagailo Y.V. et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder // Hum. Mol. Genet. – 1999. – Vol. 8, N 4. – P. 621–624. 32. Ding C.L., Zhou X., Wang B.J. et al. Association and its forensic significance between COMT gene and schizophrenia // Fa. Yi. Xue. Za. Zhi. – 2012. – Vol. 28, N 4. – P. 299–304. 33. Dobzhansky Th. The genetic nature of differences among men // Evolutionary thought in America / Ed. S. Persons. – New Haven: Yale Univer. Press, 1950. – P. 86–155. 34. Donghong L., Shuguang W., Hongbo Z. et al. Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage // J. Matern. Fetal Neonatal Med. – 2013. – Vol. 26, N 7. – P. 686–690. 35. Duff B.J., Macritchie K.A., Moorhead T.W. et al. Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review // Schizophr. Res. – 2013. – Vol. 147, N 1. – P. 1–13. 36. Frazer K.A., Eskin E., Kang H.M. et al. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains // Nature. – 2007. – Vol. 448 (7157). – P. 1050–1053. 37. Gerra G., Garofano L., Castaldini L. et al. Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents // J. Neural Transm. – 2005. – Vol. 112, N 10. – P. 1397–1410. 38. Greenberg B.D., Tolliver T.J., Huang S.J. et al. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets // J. Med. Genet. – 1999. – Vol. 88, N 1. – P. 83–87. 39. Guo J.F., Su G.Q., Zhang J.P., Wang G.Y. Genetic analysis and QTL mapping of maize yield and associate agronomic traits under semi-arid land condition // J. Biotechnol. – 2008. – Vol. 7. – P. 1829–1838. 40. Hong C.J., Pan G.M., Tsai S.J. Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism // Neuropsychobiology. – 2004. – Vol. 49, N 1. – P. 1–4. 41. Hong J.P., Lee J.S., Chung S. et al. New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia // J. Med. Genet. B. Neuropsychiatr. Genet. – 2008. – Vol. 147B, N 5. – P. 658–660. 42. Hukic D.S., Frisйn L., Backlund L. et al. Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes // PLoS One. – 2013. – Vol. 8, N 7. – Р. e67450. 43. Iafrate A.J., Feuk L., Rivera M.N. et al. Detection of large-scale variation in the human genome // J. Nat. Genet. – 2004. – Vol. 36, N 9. – P. 949–951. 44. Jimenez-Trevino L., Blasco-Fontecilla H., Braquehais M.D. et al. Endophenotypes and suicide behaviour // Actas Esp. Psiquiatr. – 2011. – Vol. 39, N 1. – P. 61–69. 45. Jonsson E.G., von Gertten C., Gustavsson J.P. et al. Androgen receptor rinucleotide repeat polymorphism and personality traits // J. Psychiatr. Genet. – 2001. – Vol. 11, N 1. – P. 19–23. 46. Kim Y.R., Jahng J.W., Min S.K. Association between the serotonin transporter gene (5-HTTLPR) and anger-related traits in Korean schizophrenic patients // Neuropsychobiology. – 2009. – Vol. 59, N 3. – P. 165–171. 47. Kim-Cohen J., Caspi A., Taylor A. et al. MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: new evidence and a meta-analysis // J. Mol. Psychiatry. – 2006. – Vol. 11, N 10. – P. 903–913. 48. Kruglyak L., Nickerson D.A. Variation is the spice of life // J. Nat. Genet. – 2001. – Vol. 27, N 3. – P. 234–236. 49. Lesch K.P., Bengel D., Heils A. et al. Association of anxietyrelated traits with a polymorphism in the serotonin transporter gene regulatory region // Science. – 1996. – Vol. 274 (5292). – P. 1527–1531. 50. Lindholm Carlstrцm E., Saetre P., Rosengren A. et al. Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia // J. Behav. Brain Funct. – 2012. – Vol. 8. – P. 24. 51. Link B.G., Phelan J. Evaluating the fundamental cause explanation for social disparities in health // Handbook of Medical Sociology. 5 ed. / Eds Chloe E. Bird, Peter Conrad, Allen M. Fremont. – Upper Saddle River, NJ: Prentice-Hall, 2000. – P. 33–43. 52. Lopez de Lara C., Brezo J., Rouleau G. et al. Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression // J. Biol. Psychiatry. – 2007. – Vol. 62, N 1. – P. 72–80. 53. Manuck S.B., Flory J.D., Ferrell R.E. et al. Aggression and angerrelated traits associated with a polymorphism of the tryptophan hydroxylase gene // J. Biol. Psychiatry. – 1999. – Vol. 45, N 5. – P. 603–614. 54. Maynard Smith J., Harper D.G.C., Brookfield J.F.Y. The evolution of aggression: can selection generate variability? // Phil. Trans. R. Soc. Lond. B. – 1988. – Vol. 319 (1196). – P. 557–570. 55. McDermott R., Tingley D., Cowden J. et al. Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation // Proc. Natl. Acad. Sci. USA. – 2009. – Vol. 106, N 7. – P. 2118–2123. 56. Melkersson K., Hulting A.L. Serotonin receptor 2A gene polymorphismsand schizophrenia: association with family history, diagnostic subtype and height in patients // Neuroendocrinol. Lett. – 2009. – Vol. 30, N 3. – P. 343–351. 57. Miles D.R., Carey G. Genetic and environmental architecture of human aggression // J. Pers. Soc. Psychol. – 1997. – Vol. 72. – P. 207–217. 58. Moffitt T.E. The new look of behavioral genetics in developmental psychopathology: gene-environment interplay in antisocial behaviors // Psychol. Bull. – 2005. – Vol. 131. – Р. 533–554. 59. Mueser K.T., Becker D.R., Torrey W.C. Work and nonvocational domains of functioning in persons with severe mental illness: a longitudinal analysis // J. Nerv. Ment. Dis. – 1997. – Vol. 185. – P. 419–426. 60. Munafт M.R., Attwood A.S., Flint J. Neuregulin 1 genotype and schizophrenia // Schizophr. Bull. – 2008. – Vol. 34, N 1. – P. 9–12. 61. New A.S., Gelernter J., Yovell Y. et al. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study // J. Med. Genet. – 1998. – Vol. 81, N 1. – P. 13–17. 62. Nielsen D.A., Goldman D., Virkkunen M. et al. Suicidality and 5-hydroxyindolacetic acid concentration associated with a tryptophan hydroxylase polymorphism // Arch. Gen. Psychiatry. – 1994. – Vol. 51. – P. 34–38. 63. O’Sullivan S.S., Evans A.H., Lees A.J. Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management // CNS Drugs. – 2009. – Vol. 23, N 2. – P. 157–170. 64. Pavlov K.A., Chistiakov D.A., Chekhonin V.P. Genetic determinants of aggression and impulsivity in humans // J. Appl. Genet. – 2012. – Vol. 53, N 1. – P. 61–82. 65. Patkar A.A., Berrettini W.H., Hoehe M. et al. No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals // Psychiatr. Genet. – 2002. – Vol. 12, N 3. – P. 161–164. 66. Perez-Rodriguez M.M., Weinstein S., New A.S. et al. Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls // J. Psychiatr. Res. – 2010. – Vol. 44, N 15. – P. 1075–1081. 67. Philibert R.A., Wernett P., Plume J. et al. Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder // Biol. Psychol. – 2011. – Vol. 87, N 3. – P. 366–371. 68. Popova N.K. From genes to aggressive behavior: the role of serotoninergic system // Bioessays. – 2006. – Vol. 28. – P. 495–503. 69. Prichard Z.M., Jorm A.F., Mackinnon A., Easteal S. Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits // Psychiatr. Genet. – 2007. – Vol. 17, N 5. – P. 299–303. 70. Rajender S., Pandu G., Sharma J.D. et al. Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior // Int. J. Legal Med. – 2008. – Vol. 122. – P. 367–372. 71. Reichborn-Kjennerud T.О. Genetics of personality disorders // J. Psychiatr. Clin. North Am. – 2008. – Vol. 31, N 3. – P. 421–440. 72. Reif A., Rosler M., Freitag C.M. et al. Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment // Neuropsychopharmacology. – 2007. – Vol. 32. – P. 2375–2383. 73. Retz W., Retz-Junginger P., Supprian T. et al. Association of serotonin transporter promoter gene polymorphism with violence: relation with personality disorders, impulsivity, and childhood ADHD psychopathology // Behav. Sci. Law. – 2004. – Vol. 22, N 3. – P. 415–425. 74. Rhee S.H., Waldman I.D. Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies // Psychol. Bull. – 2002. – Vol. 128, N 3. – P. 490–529. 75. Richard-Devantoy S., Olie J.P., Gourevitch R. Risk of homicide and major mental disorders: a critical review // Encephale. – 2009. – Vol. 35, N 6. – P. 521–530. 76. Rotberg B., Kronenberg S., Carmel M. et al. Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders // J. Child Adolesc. Psychopharmacol. – 2013. – Vol. 23 (2). – Р. 117–122. 77. Rujescu D., Giegling I., Gietl A. et al. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits // Biol. Psychiatry. – 2003. – Vol. 54, N 1. – P. 34–39. 78. Sanders A.R., Duan J., Levinson D.F. et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics // Am. J. Psychiatry. – 2008. – Vol. 165, N 4. – P. 497–506. 79. Scheuch K., Lautenschlager M., Grohmann M. et al. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons // Biol. Psychiatry. – 2007. – Vol. 62, N 11. – P. 1288–1294. 80. Schwab S.G., Wildenauer D.B. Research on causes for schizophrenia: are we close? // Schizophr. Res. – 2008. – Vol. 102, N 1–3. – P. 29–30. 81. Sebat J., Lakshmi B., Troge J. et al. Large-scale copy number polymorphism in the human genome // Science – 2004. – Vol. 305 (5683). – P. 525–528. 82. Seroczynski A.D., Bergeman C.S., Coccaro E.F. Etiology of the impulsivity/aggression relationship: genes or environment? // J. Psychiatry Res. – 1999. – Vol. 86, N 1. – P. 41–57. 83. Silva H., Iturra P., Solari A. et al. Fluoxetine response in impulsiveaggressive behavior and serotonin transporter polymorphism in personality disorder // Psychiatr. Genet. – 2010. – Vol. 20, N 1. – P. 25–30. 84. Simon N.G., Cologer-Clifford A., Lu S.F. et al. Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression // Neurosci. Biobehav. Rev. – 1998. – Vol. 23, N 2. – P. 325–336. 85. Simons R.L., Lei M.K., Beach S.R. et al. Social Environmental Variation, Plasticity Genes, and Aggression: Evidence for the Differential Susceptibility Hypothesis // J. Soc. Rev. – 2011. – Vol. 76, N 6. – P. 833–912. 86. Singh J.P., Volavka J., Czobor P., Van Dorn R.A. A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia // PLoS One. – 2012. – Vol. 7, N 8. – Р. e43423. 87. Spalletta G., Morris D.W., Angelucci F. et al. BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia // Eur. Psychiatry. – 2010. – Vol. 25. – P. 311–313. 88. Sun Y., Zhang J., Yuan Y. et al. Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population // Am. J. Med. Genet. B. Neuropsychiatr. Genet. – 2012. – Vol. 159B, N 1. – P. 104–111. 89. Sutcliffe J.S., Ryan J., Delahanty Prasad H.C. et al. Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors // Am. J. Hum. Genet. – 2005. – Vol. 77, N 2. – P. 265–279. 90. Sysoeva O.V., Maluchenko N.V., Smirnov K.S. et al. Peculiarities of brain information processing in persons with different serotonin transporter gene variants // Bull. Exp. Biol. Med. – 2009. – Vol. 148, N 5. – P. 731–734. 91. Talkowski M.E., Kirov G., Bamne M. et al. A network of dopaminergic gene variations implicated as risk factors for schizophrenia // Hum. Mol. Genet. – 2008. – Vol. 17, N 5. – P. 747–758. 92. Tee S.F., Chow T.J., Tang P.Y., Loh H.C. Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population // J. Genet. Mol. Res. – 2010. – Vol. 9, N 3. – P. 1274–1278. 93. Tosato S., Bonetto C., Di Forti M. et al. Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients // Neurosci. Lett. – 2011. – Vol. 495. –P. 17–21. 94. Tsuang H.C., Chen W.J., Lin S.H. et al. Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia // Psychiatry Res. – 2013. – Vol. 208, N 2. – P. 105–110. 95. Tsunoka T., Kishi T., Kitajima T. et al. Association analysis ofGRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population // Prog. Neuropsychopharmacol. Biol. Psychiatry. – 2010. – Vol. 34, N 4. – P. 639–644. 96. Westberg L., Eriksson E. Sex steroid-related candidate genes in psychiatric disorders // J. Psychiatry Neurosci. – 2008. – Vol. 33, N 4. – P. 319–330. 97. Westberg L., Henningsson S., Landйn M. et al. Influence of androgen receptor repeat polymorphisms on personality traits in men // J. Psychiatry Neurosci. – 2009. – Vol. 34, N 3. – P. 205–213. 98. Williams Best M., Coccaro E.F. Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder // Proc. Natl Acad. Sci. – 2002. – Vol. 99, N 12. – P. 8448–8453. 99. Wu Х., Xiao H. Progress in the detection of human genome structural Variations // Science in China. Series C: Life Sciences. – 2009. – Vol. 52, N 6. – P. 560–567. 100. Zappalainem J. Linkage of antisocial alcoholism to the serotonin 5–HTIB receptor gene in 2 population // Arch. Jen. Psychiatry. – 1998. – Vol. 55, N 11. – P. 989–994.



DOI: http://dx.doi.org/10.24411/1560-957X-2014-1%25x

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