Воспаление и нарушение системы «Перекисное окисление липидов – антиоксидантная защита» в механизмах течения посттравматического стрессового расстройства

Полный текст:   Только для подписчиков

Рекомендуемое оформление библиографической ссылки:

Озорнин А.С., Сахаров А.В. Воспаление и нарушение системы «Перекисное окисление липидов – антиоксидантная защита» в механизмах течения посттравматического стрессового расстройства // Российский психиатрический журнал. 2024. №4. С. 92-102.

Аннотация

В научном обзоре с целью анализа и систематизации литературных данных о роли маркеров воспаления и функционирования системы «Перекисное окисление липидов – антиоксидантная защита» при посттравматическом стрессовом расстройстве произведен поиск статей за период 1990–2023 гг. в базах данных PubMed и e-Library.ru. В обзоре представлены сведения о повышенном содержании периферических цитокинов и интенсификации процессов липопероксидации с ослаблением ферментативного компонента антиоксидантной защиты. Рассмотрены механизмы возникновения этих нарушений. Описаны влияния нейровоспаления и окислительного стресса на морфофункциональные нарушения головного мозга. Представленные научные результаты требуют более детальной оценки для установления новых нейробиологических и патогенетических функций нейровоспаления при посттравматическом стрессовом расстройстве.

Ключевые слова посттравматическое стрессовое расстройство; воспаление; цитокины; окислительный стресс

Литература

1. Williams T, Phillips NJ, Stein DJ, et al. Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev. 2022;3(3):CD002795. DOI: 10.1002/14651858.CD002795.pub3 2. Vasil'eva AV. [Post-traumatic stress disorder – from traumatic neurosis to ICD-11: features of diagnosis and selection of therapy]. Meditsinskii sovet [Meditsinskiy council]. 2023;17(3):94–108. (In Russ.) DOI: 10.21518/ms2023-083 3. Ressler KJ, Berretta S, Bolshakov VY, et al. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022;18(5):273–88. DOI: 10.1038/s41582-022-00635-8 4. Miller MW, Sadeh N. Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol Psychiatry. 2014;19(11):1156–62. DOI: 10.1038/mp.2014.111 5. Smulevich AB, Kolyutskaya EV, Almaev NA, et al. Posttravmaticheskoe stressovoe rasstroistvo priendogennykhzabolevaniyakh. Psikhiatriya [Psychiatry journal]. 2003;3(3):12–8. (In Russ.) 6. Karavaeva TA, Vasil'eva AV, Radionov DS. Comorbidity of post-traumatic stress disorder and psychoactive substance abuse: problems of diagnostics, etiology, pathogenesis, and approaches to psychotherapy. Voprosy narkologii [Jjournal of addiction problems]. 2022;9–10(212):75–95. (In Russ.) DOI: 10.47877/0234-0623_2022_9-10_75 7. Sukiasyan SG, Tadevosyan MYa. [Combat stress and organic brain injury: type of the dynamics of posttraumatic stress disorder]. Zh Nevrol Psikhiatr Im SS Korsakova. 2020;120(9):19–27. (In Russ.) DOI: 10.17116/jnevro202012009119 8. Suh J, Ressler KJ. Common Biological Mechanisms of Alcohol Use Disorder and Post-Traumatic Stress Disorder. Alcohol Res. 2018;39(2):131–45. PMID: 31198653 9. Tarsitani L, Vassalini P, Koukopoulos A, et al. Post-traumatic Stress Disorder Among COVID-19 Survivors at 3-Month Follow-up After Hospital Discharge. J Gen Intern Med. 2021;36(6):1702–7. DOI: 10.1007/s11606-021-06731-7 10. Arulselvan P, Fard MT, Tan WS, et al. Role of Antioxidants and Natural Products in Inflammation. Oxid Med Cell Longev. 2016;2016:5276130. DOI: 10.1155/2016/5276130 11. Davì G, Falco A. Oxidant stress, inflammation and atherogenesis. Lupus. 2005;14(9):760–4. DOI: 10.1191/0961203305lu2216oa 12. Rodríguez-Castañeda A, Martínez-González KL, Sánchez-Arenas R, et al. Estrésoxidativoenadultosmayores con diabetes mellitus o hipertensión arterial [Oxidative stress in the elderly with diabetes mellitus or hypertension]. Rev Med Inst Mex Seguro Soc. 2018;56(Suppl 1):12–7. (In Spanish) PMID: 29624343 13. Miller MW, Lin AP, Wolf EJ, et al. Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD. Harv Rev Psychiatry. 2018;26(2):57–69. DOI: 10.1097/HRP.0000000000000167 14. Uzbekov MG. Lipid peroxidation and antioxidant systems in mental disorders. Part I. Sotsial'naya i klinicheskaya psikhiatriya [Social and clinical psychiatry]. 2014;24(4):97–103. (In Russ.) 15. Uzbekov MG. Oxidative stress and depression: the problems of the pathogenesis. Sotsial'naya i klinicheskaya psikhiatriya [Social and clinical psychiatry]. 2022;32(3):73–82. (In Russ.) 16. Renault PF, Hoofnagle JH, Park Y, et al. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med. 1987;147(9):1577–80. PMID: 3307672 17. Jin R, Chan AKY, Wu J, et al. Relationships between Inflammation and Age-Related Neurocognitive Changes. Int J Mol Sci. 2022;23(20):12573. DOI: 10.3390/ijms232012573 18. Kokiko-Cochran ON, Godbout JP. The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer's Disease. Front Immunol. 2018;9:672. DOI: 10.3389/fimmu.2018.00672 19. Michopoulos V, Powers A, Gillespie CF, et al. Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond. Neuropsychopharmacology. 2017;42(1):254–70. DOI: 10.1038/npp.2016.146 20. Perry BI, Upthegrove R, Kappelmann N, et al. Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study. Brain Behav Immun. 2021;97:176–85. DOI: 10.1016/j.bbi.2021.07.009 21. Aleksandrovskii YuA, Poyurovskii MV, Neznamov GG. [Lipid peroxidation in emotional stress and neurotic disorders]. Zh Nevropatol Psikhiatr Im SS Korsakova. 1988;88(11):95–101. (In Russ.) 22. Govorin NV, Govorin AV, Skazhutin SA. [Significance of disorders of the processes of lipid peroxidation in patients with persistent paranoid schizophrenia resistant to the treatment]. Zh Nevropatol Psikhiatr Im SS Korsakova. 1991;(7):121–4. (In Russ.) 23. Hirai S, Tanaka M, Sotomatsu A. [Free radicals and degenerative diseases of the nervous system]. Nihon Ronen Igakka iZasshi. 1990;27(2):171–6. (In Japanese) PMID: 2200916 24. Liu C, Chu D, Kalantar-Zadeh K, et al. Cytokines: From Clinical Significance to Quantification. Adv Sci (Weinh). 2021;8(15):e2004433. DOI: 10.1002/advs.202004433 25. Hori H, Kim Y. Inflammation and post-traumatic stress disorder. Psychiatry Clin Neurosci. 2019;73(4):143–53. DOI: 10.1111/pcn.12820 26. Miller MW, Maniates H, Wolf EJ, et al. CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein. Brain Behav Immun. 2018;67:194–202. DOI: 10.1016/j.bbi.2017.08.022 27. von Känel R, Hepp U, Kraemer B, et al. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res. 2007;41(9):744–52. DOI: 10.1016/j.jpsychires.2006.06.009 28. Gill J, Vythilingam M, Page GG. Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD. J Trauma Stress. 2008;21(6):530–9. DOI: 10.1002/jts.20372 29. Guo M, Liu T, Guo JC, et al. Study on serum cytokine levels in posttraumatic stress disorder patients. Asian Pac J Trop Med. 2012;5(4):323–5. DOI: 10.1016/S1995-7645(12)60048-0 30. Teche SP, Rovaris DL, Aguiar BW, et al. Resilience to traumatic events related to urban violence and increased IL10 serum levels. Psychiatry Res. 2017;250:136–40. DOI: 10.1016/j.psychres.2017.01.072 31. Imai R, Hori H, Itoh M, et al. Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder. J Psychiatr Res. 2018;102:192–200. DOI: 10.1016/j.jpsychires.2018.04.009 32. de Oliveira JF, Wiener CD, Jansen K, et al. Serum levels of interleukins IL-6 and IL-10 in individuals with posttraumatic stress disorder in a population-based sample. Psychiatry Res. 2018;260:111–5. DOI: 10.1016/j.psychres.2017.11.061 33. D'Elia ATD, Juruena MF, Coimbra BM, et al. Increased immuno-inflammatory mediators in women with post-traumatic stress disorder after sexual assault: 1-Year follow-up. J Psychiatr Res. 2022;155:241–51. DOI: 10.1016/j.jpsychires.2022.08.028 34. Lindqvist D, Dhabhar FS, Mellon SH, et al. Increased pro-inflammatory milieu in combat related PTSD – A new cohort replication study. Brain Behav Immun. 2017;59:260–4. DOI: 10.1016/j.bbi.2016.09.012 35. Bruenig D, Mehta D, Morris CP, et al. Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans. Compr Psychiatry. 2017;74:125–33. DOI: 10.1016/j.comppsych.2017.01.015 36. Miller K, Driscoll D, Smith LM, et al. The Role of Inflammation in Late-Life Post-Traumatic Stress Disorder. Mil Med. 2017;182(11):1815–8. DOI: 10.7205/MILMED-D-17-00073 37. Passos IC, Vasconcelos-Moreno MP, Costa LG, et al. Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. Lancet Psychiatry. 2015;2(11):1002–12. DOI: 10.1016/S2215-0366(15)00309-0 38. Peruzzolo TL, Pinto JV, Roza TH, et al. Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis. Mol Psychiatry. 2022;27(8):3150–63. DOI: 10.1038/s41380-022-01564-0 39. NedicErjavec G, Konjevod M, NikolacPerkovic M, et al. Short overview on metabolomic approach and redox changes in psychiatric disorders. Redox Biol. 2018;14:178–86. DOI: 10.1016/j.redox.2017.09.002 40. Borovac Štefanović L, Kalinić D, Mimica N, et al. Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder. Ann ClinBiochem. 2015;52(1):95–104. DOI: 10.1177/0004563214528882 41. Murray AJ, Rogers JC, Katshu MZUH, et al. Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders. Front Psychiatry. 2021;12:703452. DOI: 10.3389/fpsyt.2021.703452 42. Tezcan E, Atmaca M, Kuloglu M, et al. Free radicals in patients with post-traumatic stress disorder. Eur Arch Psychiatry Clin Neurosci. 2003;253(2):89–91. DOI: 10.1007/s00406-003-0413-x 43. Ceprnja M, Derek L, Unić A, et al. Oxidative stress markers in patients with post-traumatic stress disorder. Coll Antropol. 2011;35(4):1155–60. PMID: 22397253 44. Atli A, Bulut M, Bez Y, et al. Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors. Eur Arch Psychiatry Clin Neurosci. 2016;266(4):329–36. DOI: 10.1007/s00406-015-0638-5 45. Ogłodek EA, Just MJ. The association between inflammatory markers (iNOS, HO-1, IL-33, MIP-1β) and depression with and without posttraumatic stress disorder. Pharmacol Rep. 2018;70(6):1065–72. DOI: 10.1016/j.pharep.2018.06.001 46. Perković MN, Milković L, Uzun S, et al. Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder. Biomolecules. 2021;11(9):1365. DOI: 10.3390/biom11091365 47. Morris MC, Compas BE, Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin Psychol Rev. 2012;32(4):301–15. DOI: 10.1016/j.cpr.2012.02.002 48. Stupin KN, Zen'ko MYu, Rybnikova EA. Comparative Analysis of Pathobiochemical Changes in Major Depression and Post-Traumatic Stress Disorder. Biochemistry (Mosc). 2021;86(6):885–93. (In Russ.) DOI: 10.1134/S0006297921060109 49. Lapshin MS, Kondashevskaya MV, Epishev VV, et al. Pathogenesis of post-traumatic stress disorder, therapeutic targets. Uspekhi fiziologicheskikh nauk [Progress in physiological science]. 2023;54(1):55–69. (In Russ.) DOI: 10.31857/S0301179823010058 50. Kempuraj D, Selvakumar GP, Thangavel R, et al. Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis. Front Neurosci. 2017;11:703. DOI: 10.3389/fnins.2017.00703 51. Tuchina OP, Sidorova MV, Turkin AV, et al. Molecular mechanisms of neuroinflammation initiation and development in a model of post-traumatic stress disorder. Genes & Cells. 2018;13(2):47–55. (In Russ.) DOI: 10.23868/201808019 52. Dmytriv TR, Tsiumpala SA, Semchyshyn HM, et al. Mitochondrial dysfunction as a possible trigger of neuroinflammation at post-traumatic stress disorder (PTSD). Front Physiol. 2023;14:1222826. DOI: 10.3389/fphys.2023.1222826 53. Manzoor MF, Arif Z, Kabir A, et al. Oxidative stress and metabolic diseases: Relevance and therapeutic strategies. Front Nutr. 2022;9:994309. DOI: 10.3389/fnut.2022.994309 54. Voitsekhovska VV, Voitsekhovska YuG, Shkesters A, et al. [Advances of selenium supplementation in posttraumatic stress disorder risk group patients]. Biomed Khim. 2014;60(1):125–32. (In Russ.) PMID: 24749253 55. Lee DH, Lee JY, Hong DY, et al. Neuroinflammation in Post-Traumatic Stress Disorder. Biomedicines. 2022;10(5):953. DOI: 10.3390/biomedicines10050953 56. Katrinli S, Oliveira NCS, Felger JC, et al. The role of the immune system in posttraumatic stress disorder. Transl Psychiatry. 2022;12(1):313. DOI: 10.1038/s41398-022-02094-7 57. Huang X, Hussain B, Chang J. Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms. CNS Neurosci Ther. 2021;27(1):36–47. DOI: 10.1111/cns.13569 58. Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019;10:1827. DOI: 10.3389/fimmu.2019.01827 59. Gasanov RF, Makarov IV, Emelina DA, et al. Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review). Obozrenie psikhiatrii i meditsinskoi psikhologii im VM Bekhtereva [VM Bekhterev review of psychiatry and medical psychology]. 2023;57(1):8–22. (In Russ.) DOI: 10.31363/2313-7053-2023-699 60. Nisar S, Bhat AA, Hashem S, et al. Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder. Int J Mol Sci. 2020;21(12):4503. DOI: 10.3390/ijms2112450

Метрики статей

Загрузка метрик ...

Metrics powered by PLOS ALM