Корреляция уровней экспрессии генов BDNF и OXTR в головном мозге с показателями тревожного и депрессивно-подобного поведения у крыс с опытом ультразвукового пренатального стресса

В контролируемом эксперименте с целью оценить влияние ультразвукового пренатального стресса на экспрессию генов BDNF и OXTR в головном мозге крыс линии Sprague Dawley на беременных самок непрерывно воздействовали ультразвуком переменной частоты в течение всего гестационного периода. Потомство самок во взрослом возрасте тестировали в поведенческих тестах: тесте на ангедонию, тесте «Открытое поле», тесте «Приподнятый крестообразный лабиринт». В образцах головного мозга потомства из разных отделов (гиппокамп, гипоталамус и средний мозг) оценивали уровень экспрессии генов BDNF и OXTR методом полимеразной цепной реакции в реальном времени. Потомство крыс с опытом пренатального стресса характеризовалось измененным поведенческим фенотипом – усиленным тревожным и исследовательским поведением. Экспрессия генов BDNF и OXTR не изменилась, однако были обнаружены некоторые корреляционные взаимосвязи между экспрессией и поведением.

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