Genome-wide association studies of alcohol dependence syndrome and alcohol abuse

In this cross-sectional retrospective study with the aim of studying the genetic basis of alcohol use disorder (AUD), a genome-wide association study was conducted in a cohort of patients with AUD and in a cohort of individuals who abuse alcohol but do not have the diagnosis and clinical signs of AUD. Clustering of the results of the genome-wide association study was performed to identify common genetic mechanisms that contribute to the development of addictive behavior. As a result, genetic polymorphisms associated with both AUD and alcohol abuse were found. Given that genetics determines only part of the risk, we analyzed the main socio-demographic factors traditionally associated with AUD. The obtained results demonstrate that certain genetic factors associated with a clinical diagnosis of AUD distinguish this group from individuals who abuse alcohol but do not have the diagnosis.

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