Поиск полногеномных ассоциаций с синдромом зависимости от алкоголя и злоупотреблением алкоголем

В одномоментном ретроспективном исследовании с целью изучения генетической основы синдрома зависимости от алкоголя (СЗА) был проведен поиск полногеномных ассоциаций в когорте пациентов с СЗА, а также в когорте лиц, злоупотребляющих алкоголем, но не имеющих установленного диагноза и клинических признаков СЗА. С целью выявления общих генетических механизмов, способствующих развитию аддиктивного поведения, была проведена кластеризация результатов поиска полногеномных ассоциаций. В результате были обнаружены генетические полиморфизмы, ассоциированные как с СЗА, так и со злоупотреблением алкоголем. С учетом того, что генетика обуславливает только часть риска развития СЗА, мы проанализировали основные социо-демографические факторы, традиционно ассоциированные с алкоголизмом. Полученные результаты демонстрируют, что определенные генетические факторы, ассоциированные с клиническим диагнозом СЗА, отличают эту группу от лиц, злоупотребляющих алкоголем, но не имеющих данного диагноза.

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