Clinical characteristics of early-onset depression: focus on neurovegetative symptoms

Evgeniy Dmitrievich Kas'yanov; Anton Evgen'evich Nikolishin; Grigoriy Viktorovich Rukavishnikov; Tat'yana Viktorovna Lezheyko; Anna Emirovna Gareeva; Anastasiya Valer'evna Kazanceva; Kristina Sergeevna Savickaya; Ivan Dmitrievich Saraev; Larisa Vladimirovna Malyshko; Viktor Aleksandrovich Soldatkin; El'za Kamilevna Khusnutdinova; Rinat Gayanovich Valinurov; Il'giz Faritovich Timerbulatov; Aleksandr Sergeevich Berezkin; Vera Evgen'evna Golimbet; Nikolay Grigor'evich Neznanov; Aleksandr Olegovich Kibitov; Galina Elevna Mazo

doi:10.47877/1560-957Х-2021-10205

Clinical characteristics of early-onset depression: focus on neurovegetative symptoms

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Kas'yanov ED, Nikolishin AE, Rukavishnikov GV, et al. [Clinical characteristics of early-onset depression: focus on neurovegetative symptoms]. Rossiiskii psikhiatricheskii zhurnal [Russian Journal of Psychiatry]. 2021;(2):43-53. Russian

Abstract

A cross-sectional, multicenter study by the Russian National Consortium for Psychiatric Genetics enrolled 172 patients with depression in order to analyze the clinical features of the course of early-onset depression. Early-onset depression is associated with hypersomnia and decreased libido, as well as higher severity of the current depressive episode. In addition, early-onset depression is associated with the presence of concomitant obsessive-compulsive disorder and, in combination with family history of mood disorders, with a longer duration of the depressive episode. Early onset depression is an important trait representing a genetic influence on the development of depression. Further clinical and genetic studies are needed to investigate the specific effects of age of onset on the clinical manifestations and course of depression.

Keywords depression; early onset; neurovegetative symptoms; genetics

References

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DOI: http://dx.doi.org/10.47877/1560-957Х-2021-10205

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