Клинические особенности депрессии с ранним манифестом: фокус на нейровегетативные симптомы

В кросс-секционное мультицентровое исследование Российского национального консорциума по психиатрической генетике с целью анализа клинических особенностей течения депрессии у пациентов с ранним манифестом было включено 172 пациента. Ранний манифест депрессии ассоциирован с гиперсомнией и пониженным либидо, а также с более высокой тяжестью текущего депрессивного эпизода. Кроме того, ранний манифест ассоциирован с наличием сопутствующего обсессивно-компульсивного расстройства и, в сочетании с семейной отягощённостью, с более длительной продолжительностью депрессивного эпизода. Ранний манифест является важным признаком, отражающим генетическое влияние на развитие депрессии. Необходимы дальнейшие клинические и генетические исследования для изучения специфических эффектов возраста начала депрессии на её клинические проявления и течение.

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