Нейротрофический фактор головного мозга: структура и взаимодействие с рецепторами
Рекомендуемое оформление библиографической ссылки:
Фоминова У.Н., Гурина О.И., Шепелева И.И., Попова Т.Н., Кекелидзе З.И., Чехонин В.П. Нейротрофический фактор головного мозга: структура и взаимодействие с рецепторами // Российский психиатрический журнал. 2018. №4. С. 64-72.
В научном обзоре с целью исследования структуры нейротрофического фактора головного
мозга, а также взаимодействия его изоформ с основными рецепторами – TrkB и p75NTR –
проведён анализ российских и зарубежных публикаций, связанных с данной темой. Также
уделено внимание основным механизмам активации сигнальных путей при взаимодействии
белка с рецепторами, описана возможная роль TrkB и p75NTR в патогенезе депрессии,
рассмотрено вероятное влияние дисбаланса этих рецепторов на развитие данного
заболевания. Это определяет новизну работы и стратегию дальнейшего исследования
механизмов взаимосвязи нейротрофического фактора головного мозга и депрессии.
Проанализировано более 200 источников, 40 из них включены в обзор.
Ключевые слова нейротрофический фактор головного мозга (BDNF), рецепторы, pro-BDNF, m-BDNF
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DOI: http://dx.doi.org/10.24411/1560-957X-2018-1%25x
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